Stem Cell Origins of Leukaemia and Curability

Overview

Journal Br J Cancer

Specialty Oncology

Date 1993 Mar 1

PMID 8439493

Citations 12

Authors

M F Greaves

Affiliations

Soon will be listed here.

Abstract

It is suggested that most childhood acute lymphoblastic leukaemias and some other paediatric cancers are chemo-curable because they arise in stem cell populations that are functionally transient, chemosensitive and programmed for apoptosis. Most adult acute leukaemias are chemo-incurable at least in part because they originate in relatively drug resistant stem cells with extensive self-renewal capacity. The latter property in turn increases the probability of clones evolving with multi-drug resistance. Particular mutations may superimpose additional adverse features on leukaemic cells.

Citing Articles

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Chemotherapy curable malignancies and cancer stem cells: a biological review and hypothesis.

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Childhood leukaemia and lymphoma: African experience supports a role for environmental factors in leukaemogenesis.

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Stem cell programs are retained in human leukemic lymphoblasts.

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Loss of p19Arf in a Rag1(-/-) B-cell precursor population initiates acute B-lymphoblastic leukemia.

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