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Fluoroquinolone Resistance Protein NorA of Staphylococcus Aureus is a Multidrug Efflux Transporter

Overview
Journal Antimicrob Agents Chemother
Publisher American Society for Microbiology
Specialty Pharmacology
Date 1993 Jan 1
PMID 8431010
Citations 121
Authors
A A NEYFAKH
C M Borsch
G W Kaatz
Affiliations
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Abstract

The gene of the Staphylococcus aureus fluoroquinolone efflux transporter protein NorA confers resistance to a number of structurally dissimilar drugs, not just to fluoroquinolones, when it is expressed in Bacillus subtilis. NorA provides B. subtilis with resistance to the same drugs and to a similar extent as the B. subtilis multidrug transporter protein Bmr does. NorA and Bmr share 44% sequence similarity. Both the NorA- and Bmr-conferred resistances can be completely reversed by reserpine.

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References
1.
Ohshita Y, Hiramatsu K, Yokota T . A point mutation in norA gene is responsible for quinolone resistance in Staphylococcus aureus. Biochem Biophys Res Commun. 1990; 172(3):1028-34. DOI: 10.1016/0006-291x(90)91549-8. View
2.
Yoshida H, Bogaki M, Nakamura S, Ubukata K, Konno M . Nucleotide sequence and characterization of the Staphylococcus aureus norA gene, which confers resistance to quinolones. J Bacteriol. 1990; 172(12):6942-9. PMC: 210814. DOI: 10.1128/jb.172.12.6942-6949.1990. View
3.
NEYFAKH A . The multidrug efflux transporter of Bacillus subtilis is a structural and functional homolog of the Staphylococcus NorA protein. Antimicrob Agents Chemother. 1992; 36(2):484-5. PMC: 188464. DOI: 10.1128/AAC.36.2.484. View
4.
NEYFAKH A, Bidnenko V, Chen L . Efflux-mediated multidrug resistance in Bacillus subtilis: similarities and dissimilarities with the mammalian system. Proc Natl Acad Sci U S A. 1991; 88(11):4781-5. PMC: 51750. DOI: 10.1073/pnas.88.11.4781. View
5.
Kaatz G, Seo S, Ruble C . Mechanisms of fluoroquinolone resistance in Staphylococcus aureus. J Infect Dis. 1991; 163(5):1080-6. DOI: 10.1093/infdis/163.5.1080. View