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Differential Effects of Hydroxocobalamin on NO-mediated Relaxations in Rat Aorta and Anococcygeus Muscle

Overview
Journal Br J Pharmacol
Publisher Wiley
Specialty Pharmacology
Date 1993 Jan 1
PMID 8428210
Citations 30
Authors
M A Rajanayagam
C G Li
M J Rand
Affiliations
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Abstract

In rat aortic rings, hydroxocobalamin (10-30 microM) produced concentration-dependent reductions of the relaxant action of nitric oxide (NO) and the endothelium-dependent, NO-mediated, relaxant action of acetylcholine. In anococcygeus muscles, hydroxocobalamin (10-30 microM) reduced but also prolonged, NO-induced relaxations, but had no effect on non-adrenergic, non-cholinergic-mediated relaxations. Hydroxocobalamin had no effect on the NO-independent relaxant action of papaverine in either tissue. It is suggested that hydroxocobalamin sequesters NO by forming nitrosocobalamin. Nitrosocobalamin did not relax aortic rings, but produced a slowly developing and prolonged relaxation of anococcygeus muscles.

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