Transplacental Transmission of a Leukemogenic Murine Leukemia Virus

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1993 Oct 1

PMID 8396671

Citations 7

Authors

H G Bedigian

L A Shepel

P C Hoppe

Affiliations

Soon will be listed here.

Abstract

Recombinant inbred BXH-2 mice spontaneously produce a B-tropic murine leukemia virus (MuLV) beginning early in life and have a high incidence of spontaneous myeloid leukemia. These traits are not characteristic of the progenitor strains (C57BL/6J and C3H/HeJ) or of 11 other recombinant inbred BXH strains. Genetic analysis has shown that the virus is not transmitted through the germ line, suggesting that the virus is passed from one generation to the next by horizontal transmission. An additional ecotropic proviral locus was detected in some mice of this strain after several generations of inbreeding. We show that BXH ecotropic virus was transmitted to other strains when fostered on viremic BXH-2 mice and that these mice go on to develop tumors of hematopoietic origin. Our earlier finding that virus is expressed early in gestation suggested that the ecotropic MuLV is also transmitted in utero. In order to determine the stage at which the ecotropic MuLV is transmitted in utero, preimplantation stage embryos were transferred to the uteri of recipient ecotropic virus-negative mice. These mice were found to be negative for the presence of the ecotropic MuLV, suggesting that transplacental transmission of the ecotropic virus readily occurs in BXH-2 mice. Although other viruses, including human lentiviruses, are transmitted across the placental barrier, transplacental transmission of MuLV is a rare event. Thus, the BXH-2 mouse strain may contribute to our understanding of the mechanism of transplacental transmission and pathogenesis and offers a potential new model for use in drug therapy of exogenously transmitted viruses related to lentiviruses.

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References

Jaenisch R . Retroviruses and embryogenesis: microinjection of Moloney leukemia virus into midgestation mouse embryos. Cell. 1980; 19(1):181-8. DOI: 10.1016/0092-8674(80)90399-2. View

Golovkina T, Chervonsky A, Dudley J, Ross S . Transgenic mouse mammary tumor virus superantigen expression prevents viral infection. Cell. 1992; 69(4):637-45. DOI: 10.1016/0092-8674(92)90227-4. View

Rowe W, Kozak C . Germ-line reinsertions of AKR murine leukemia virus genomes in Akv-1 congenic mice. Proc Natl Acad Sci U S A. 1980; 77(8):4871-4. PMC: 349950. DOI: 10.1073/pnas.77.8.4871. View

Chattopadhyay S, Lander M, Rands E, Lowy D . Structure of endogenous murine leukemia virus DNA in mouse genomes. Proc Natl Acad Sci U S A. 1980; 77(10):5774-8. PMC: 350153. DOI: 10.1073/pnas.77.10.5774. View

Bedigian H, Taylor B, Meier H . Expression of murine leukemia viruses in the highly lymphomatous BXH-2 recombinant inbred mouse strain. J Virol. 1981; 39(2):632-40. PMC: 171373. DOI: 10.1128/JVI.39.2.632-640.1981. View

Jenkins N, Copeland N, Taylor B, Bedigian H, Lee B . Ecotropic murine leukemia virus DNA content of normal and lymphomatous tissues of BXH-2 recombinant inbred mice. J Virol. 1982; 42(2):379-88. PMC: 256863. DOI: 10.1128/JVI.42.2.379-388.1982. View

Quint W, van der Putten H, Janssen F, Berns A . Mobility of endogenous ecotropic murine leukemia viral genomes within mouse chromosomal DNA and integration of a mink cell focus-forming virus-type recombinant provirus in the germ line. J Virol. 1982; 41(3):901-8. PMC: 256826. DOI: 10.1128/JVI.41.3.901-908.1982. View

Herr W, Gilbert W . Somatically acquired recombinant murine leukemia proviruses in thymic leukemias of AKR/J mice. J Virol. 1983; 46(1):70-82. PMC: 255094. DOI: 10.1128/JVI.46.1.70-82.1983. View

Bedigian H, Johnson D, Jenkins N, Copeland N, Evans R . Spontaneous and induced leukemias of myeloid origin in recombinant inbred BXH mice. J Virol. 1984; 51(3):586-94. PMC: 255802. DOI: 10.1128/JVI.51.3.586-594.1984. View

10.

Jenkins N, Copeland N . High frequency germline acquisition of ecotropic MuLV proviruses in SWR/J-RF/J hybrid mice. Cell. 1985; 43(3 Pt 2):811-9. DOI: 10.1016/0092-8674(85)90254-5. View

11.

Portis J, McAtee F, Hayes S . Horizontal transmission of murine retroviruses. J Virol. 1987; 61(4):1037-44. PMC: 254060. DOI: 10.1128/JVI.61.4.1037-1044.1987. View

12.

Kiessling A, Crowell R, CONNELL R . Sperm-associated retroviruses in the mouse epididymis. Proc Natl Acad Sci U S A. 1987; 84(23):8667-71. PMC: 299607. DOI: 10.1073/pnas.84.23.8667. View

13.

Miller S, Dykes D, Polesky H . A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 1988; 16(3):1215. PMC: 334765. DOI: 10.1093/nar/16.3.1215. View

14.

McCune J . HIV-1: the infective process in vivo. Cell. 1991; 64(2):351-63. DOI: 10.1016/0092-8674(91)90644-e. View

15.

Marrack P, KUSHNIR E, Kappler J . A maternally inherited superantigen encoded by a mammary tumour virus. Nature. 1991; 349(6309):524-6. DOI: 10.1038/349524a0. View

16.

BEAR S, Tsichlis P, Schwartz R . H-2-mediated resistance to an ecotropic type C retrovirus: localization of controlling genes and ontogenic studies of resistance. Immunogenetics. 1980; 11(5):451-65. DOI: 10.1007/BF01567814. View

17.

Imberti L, Sottini A, Bettinardi A, Puoti M, Primi D . Selective depletion in HIV infection of T cells that bear specific T cell receptor V beta sequences. Science. 1991; 254(5033):860-2. DOI: 10.1126/science.1948066. View

18.

Melief C, Vlug A, de Goede R, De Bruyne C, Barendsen W, de Greeve P . Naturally occurring leukemia viruses in H-2 congenic C57BL mice. I. High lymphoma incidence following milk-borne transmission of virus. J Natl Cancer Inst. 1980; 64(5):1179-89. View