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Selective Depletion in HIV Infection of T Cells That Bear Specific T Cell Receptor V Beta Sequences

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Journal Science
Specialty Science
Date 1991 Nov 8
PMID 1948066
Citations 67
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Abstract

The mechanism of T cell depletion during infection with the human immunodeficiency virus (HIV) is unclear. Examination of the repertoire of T cell receptor V (variable) regions in persons infected with HIV revealed the absence of a common set of V beta regions, whereas V alpha usage was normal. The lack of these V beta segments did not appear to correlate with opportunistic infections. The selective elimination of T cells that express a defined set of V beta sequences may indicate the presence of an HIV-encoded superantigen, similar to those encoded by the long terminal repeat of the mouse mammary tumor virus.

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