Parainfluenza Type 1 Virus-infected Cells Are Killed by Both CD8+ and CD4+ Cytotoxic T Cell Precursors

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1993 Sep 1

PMID 8396514

Citations 3

Authors

K S Slobod

J E Allan

Affiliations

Soon will be listed here.

Abstract

The memory cytotoxic T lymphocyte (CTL) response to human parainfluenza type 1 virus (hPIV-1), a prominent cause of respiratory infection in young children, has been analysed for a panel of healthy adults. The CTL response to the parainfluenza viruses has not been investigated previously. Precursor CTL (CTLp) with activity against hPIV-1-infected Epstein-Barr virus (EBV)-transformed B lymphoblastoid target cells were found at a relatively high precursor frequency (approximately 1/2500-1/4700 CD8+ and CD4+ subsets respectively) in peripheral blood. Both CD4+ and CD8+ CTLp were detected by the analysis of individual microcultures set up under limiting dilution conditions from freshly isolated blood, the phenotype of the responder cell from individual wells being determined by flow cytometry. Further characterization of the CTL response demonstrated MHC restriction by the HLA-A2 glycoprotein in 3/4 HLA-A2+ donors. The presence of effective, hPIV-1-directed T cell memory may explain, in part, the protection observed in the adult population.

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References

Kaplan D, Griffith R, Braciale V, Braciale T . Influenza virus-specific human cytotoxic T cell clones: heterogeneity in antigenic specificity and restriction by class II MHC products. Cell Immunol. 1984; 88(1):193-206. DOI: 10.1016/0008-8749(84)90064-9. View

Yasukawa M, Zarling J . Human cytotoxic T cell clones directed against herpes simplex virus-infected cells. I. Lysis restricted by HLA class II MB and DR antigens. J Immunol. 1984; 133(1):422-7. View

Gotch F, McMichael A, Smith G, Moss B . Identification of viral molecules recognized by influenza-specific human cytotoxic T lymphocytes. J Exp Med. 1987; 165(2):408-16. PMC: 2188513. DOI: 10.1084/jem.165.2.408. View

Walker B, Chakrabarti S, Moss B, Paradis T, Flynn T, Durno A . HIV-specific cytotoxic T lymphocytes in seropositive individuals. Nature. 1987; 328(6128):345-8. DOI: 10.1038/328345a0. View

Josephs S, Kim H, BRANDT C, PARROTT R . Parainfluenza 3 virus and other common respiratory pathogens in children with human immunodeficiency virus infection. Pediatr Infect Dis J. 1988; 7(3):207-9. View

Murphy B, Prince G, Collins P, Van Wyke Coelingh K, Olmsted R, Spriggs M . Current approaches to the development of vaccines effective against parainfluenza and respiratory syncytial viruses. Virus Res. 1988; 11(1):1-15. DOI: 10.1016/0168-1702(88)90063-9. View

Hoffenbach A, Langlade-Demoyen P, Dadaglio G, Vilmer E, Michel F, Mayaud C . Unusually high frequencies of HIV-specific cytotoxic T lymphocytes in humans. J Immunol. 1989; 142(2):452-62. View

van Binnendijk R, Poelen M, de Vries P, VOORMA H, Osterhaus A, UytdeHaag F . Measles virus-specific human T cell clones. Characterization of specificity and function of CD4+ helper/cytotoxic and CD8+ cytotoxic T cell clones. J Immunol. 1989; 142(8):2847-54. View

Kurane I, Meager A, Ennis F . Dengue virus-specific human T cell clones. Serotype crossreactive proliferation, interferon gamma production, and cytotoxic activity. J Exp Med. 1989; 170(3):763-75. PMC: 2189437. DOI: 10.1084/jem.170.3.763. View

10.

Yasukawa M, Inatsuki A, Kobayashi Y . Differential in vitro activation of CD4+CD8- and CD8+CD4- herpes simplex virus-specific human cytotoxic T cells. J Immunol. 1989; 143(6):2051-7. View

11.

Heilman C . From the National Institute of Allergy and Infectious Diseases and the World Health Organization. Respiratory syncytial and parainfluenza viruses. J Infect Dis. 1990; 161(3):402-6. DOI: 10.1093/infdis/161.3.402. View

12.

Walker B, Plata F . Cytotoxic T lymphocytes against HIV. AIDS. 1990; 4(3):177-84. DOI: 10.1097/00002030-199003000-00001. View

13.

Blanck G, Lok M, Kok K, DOWNIE E, Korn J, Strominger J . Gamma-interferon induction of HLA class II mRNAs in dermal fibroblasts studied by RNAse protection analysis. Hum Immunol. 1990; 29(2):150-6. DOI: 10.1016/0198-8859(90)90078-4. View

14.

Arvin A, Sharp M, Smith S, Koropchak C, Diaz P, Kinchington P . Equivalent recognition of a varicella-zoster virus immediate early protein (IE62) and glycoprotein I by cytotoxic T lymphocytes of either CD4+ or CD8+ phenotype. J Immunol. 1991; 146(1):257-64. View

15.

Eichelberger M, Allan W, Zijlstra M, Jaenisch R, Doherty P . Clearance of influenza virus respiratory infection in mice lacking class I major histocompatibility complex-restricted CD8+ T cells. J Exp Med. 1991; 174(4):875-80. PMC: 2118969. DOI: 10.1084/jem.174.4.875. View

16.

Wendt C, Weisdorf D, Jordan M, Balfour Jr H, Hertz M . Parainfluenza virus respiratory infection after bone marrow transplantation. N Engl J Med. 1992; 326(14):921-6. DOI: 10.1056/NEJM199204023261404. View

17.

Doherty P, Allan W, Eichelberger M, Carding S . Roles of alpha beta and gamma delta T cell subsets in viral immunity. Annu Rev Immunol. 1992; 10:123-51. DOI: 10.1146/annurev.iy.10.040192.001011. View

18.

Chanock R, PARROTT R, Johnson K, Kapikian A, Bell J . MYXOVIRUSES: PARAINFLUENZA. Am Rev Respir Dis. 1963; 88:SUPPL 152-66. DOI: 10.1164/arrd.1963.88.3P2.152. View

19.

Rickinson A, Wallace L, Epstein M . HLA-restricted T-cell recognition of Epstein-Barr virus-infected B cells. Nature. 1980; 283(5750):865-7. DOI: 10.1038/283865a0. View

20.

Quinnan Jr G, Kirmani N, Esber E, Saral R, Manischewitz J, Rogers J . HLA-restricted cytotoxic T lymphocyte and nonthymic cytotoxic lymphocyte responses to cytomegalovirus infection of bone marrow transplant recipients. J Immunol. 1981; 126(5):2036-41. View