Multispecific and Heterogeneous Recognition of the Gag Protein by Cytotoxic T Lymphocytes (CTL) from HIV-infected Patients: Factors Other Than the MHC Control the Epitopic Specificities

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1994 Sep 1

PMID 7521806

Citations 3

Authors

F Buseyne

G Janvier

B Fleury

D Schmidt

Y Riviere

Affiliations

Soon will be listed here.

Abstract

The HIV gag polyprotein is a major target for recognition by CTL in infected humans. Using recombinant vaccinia viruses (rVV) expressing truncations of the p24gag, and the p18gag, p15gag and HIV-2 p56gag proteins, the characterization of epitope regions recognized by in vitro-stimulated peripheral blood mononuclear cells (PBMC) from 18 infected patients has been studied. The gag-specific response of most individuals is polyclonal and multispecific, and interindividual variations between target epitope regions were frequently observed, despite shared MHC alleles. As CTL may play an important role in the control of HIV replication in infected hosts, these results have important implications for designing vaccine strategies.

Citing Articles

LAMP-1 Chimeric to HIV-1 p55Gag in the Immunization of Neonate Mice Induces an Early Germinal Center Formation and AID Expression.

Emidio Teixeira F, Oliveira L, Pietrobon A, de Salles E, DImperio Lima M, Viana I Vaccines (Basel). 2022; 10(8).

PMID: 36016134 PMC: 9414238. DOI: 10.3390/vaccines10081246.

Patient-specific cytotoxic T-lymphocyte cross-recognition of naturally occurring variants of a human immunodeficiency virus type 1 (HIV-1) p24gag epitope by HIV-1-infected children.

Buseyne F, Chaix M, Rouzioux C, Blanche S, Riviere Y J Virol. 2001; 75(10):4941-6.

PMID: 11312369 PMC: 114252. DOI: 10.1128/JVI.75.10.4941-4946.2001.

Identification of HIV protein-derived cytotoxic T lymphocyte (CTL) epitopes for their possible use as synthetic vaccine.

Brander C, Pichler W, Corradin G Clin Exp Immunol. 1995; 101(1):107-13.

PMID: 7621579 PMC: 1553304. DOI: 10.1111/j.1365-2249.1995.tb02285.x.

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