Henoch-Schönlein Purpura with Ileitis Terminalis

Overview

Journal Clin Investig

Specialty General Medicine

Date 1993 Jul 1

PMID 8374251

Citations 7

Authors

W A Scherbaum

R Kaufmann

U Vogel

G Adler

Affiliations

Soon will be listed here.

Abstract

Gastrointestinal manifestations of Henoch-Schönlein purpura commonly include abdominal pain and gastrointestinal bleeding as well as extraintestinal signs and symptoms. We report here on a 24-year-old man with gastrointestinal pain in whom the classical features of Henoch-Schönlein purpura appeared only 6 days after acute abdominal symptoms. At endoscopic investigation inflammation with aphthous lesions was detected at the terminal ileum, which is a common feature of Crohn's disease. The observation that vasculitic disorders such as Henoch-Schönlein purpura can present with inflammatory lesions at the terminal ileum which are indistinguishable from those of Crohn's disease underlines the potential vasculitic basis of the latter condition.

Citing Articles

Multisystemic manifestations of IgA vasculitis.

Du L, Wang P, Liu C, Li S, Yue S, Yang Y Clin Rheumatol. 2020; 40(1):43-52.

PMID: 32557258 DOI: 10.1007/s10067-020-05166-5.

Henoch-Schönlein Purpura Presenting as Terminal Ileitis: Case Report and Review of Unusual Causes of Ileitis.

Sanft T, Barrett T, Barr W, Jones M Gastroenterol Hepatol (N Y). 2017; 2(5):375-378.

PMID: 28289341 PMC: 5338191.

Henoch-Schönlein purpura in two pediatric patients presenting as terminal ileitis.

Kanik A, Kose E, Baran M, Kose S, Eliacik K, Sayan A Dig Dis Sci. 2014; 60(1):269-71.

PMID: 25052148 DOI: 10.1007/s10620-014-3273-5.

Terminal ileitis is not always Crohn's disease.

Bojic D, Markovic S Ann Gastroenterol. 2014; 24(4):271-275.

PMID: 24713761 PMC: 3959324.

Mesenteric vasculitis in adults with Henoch-Schonlein purpura: a not-so-benign condition.

Sibartie V, OLeary P, Peirce T Ir J Med Sci. 2009; 181(2):269-71.

PMID: 19198974 DOI: 10.1007/s11845-009-0287-7.

References

Goldbloom R, DRUMMOND K . Anaphylactoid purpura with massive gastrointestinal hemorrhage and glomerulonephritis. An unusual case treated successfully with azathioprine and corticosteroids. Am J Dis Child. 1968; 116(1):97-102. DOI: 10.1001/archpedi.1968.02100020099015. View

Salgame P, Abrams J, Clayberger C, Goldstein H, Convit J, Modlin R . Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Science. 1991; 254(5029):279-82. DOI: 10.1126/science.254.5029.279. View

SAMS Jr W . Necrotizing vasculitis. J Am Acad Dermatol. 1980; 3(1):1-13. DOI: 10.1016/s0190-9622(80)80215-5. View

Haase G, Ernster J, Bailey W . Surgical complications in Henoch-Schönlein Purpura. J Pediatr Surg. 1984; 19(4):434-6. DOI: 10.1016/s0022-3468(84)80269-9. View

Devaney K, Travis W, Hoffman G, Leavitt R, Lebovics R, Fauci A . Interpretation of head and neck biopsies in Wegener's granulomatosis. A pathologic study of 126 biopsies in 70 patients. Am J Surg Pathol. 1990; 14(6):555-64. DOI: 10.1097/00000478-199006000-00006. View

Farmer R, HAWK W, TURNBULL Jr R . Clinical patterns in Crohn's disease: a statistical study of 615 cases. Gastroenterology. 1975; 68(4 Pt 1):627-35. View

Wakefield A, Sawyerr A, Dhillon A, Pittilo R, Rowles P, Lewis A . Pathogenesis of Crohn's disease: multifocal gastrointestinal infarction. Lancet. 1989; 2(8671):1057-62. DOI: 10.1016/s0140-6736(89)91078-7. View

RANKIN G, Watts H, MELNYK C, KELLEY Jr M . National Cooperative Crohn's Disease Study: extraintestinal manifestations and perianal complications. Gastroenterology. 1979; 77(4 Pt 2):914-20. View

Tomomasa T, Hsu J, Itoh K, KUROUME T . Endoscopic findings in pediatric patients with Henoch-Schonlein purpura and gastrointestinal symptoms. J Pediatr Gastroenterol Nutr. 1987; 6(5):725-9. DOI: 10.1097/00005176-198709000-00012. View

10.

Peeters A, van den Wall Bake A, Daha M, Breeveld F . Inflammatory bowel disease and ankylosing spondylitis associated with cutaneous vasculitis, glomerulonephritis, and circulating IgA immune complexes. Ann Rheum Dis. 1990; 49(8):638-40. PMC: 1004183. DOI: 10.1136/ard.49.8.638. View

11.

Goldstein A, White R, Akuse R, Chantler C . Long-term follow-up of childhood Henoch-Schönlein nephritis. Lancet. 1992; 339(8788):280-2. DOI: 10.1016/0140-6736(92)91341-5. View

12.

Greenstein A, Janowitz H, Sachar D . The extra-intestinal complications of Crohn's disease and ulcerative colitis: a study of 700 patients. Medicine (Baltimore). 1976; 55(5):401-12. DOI: 10.1097/00005792-197609000-00004. View

13.

ZEEK P, Smith C, WEETER J . Studies on periarteritis nodosa; the differentiation between the vascular lesions of periarteritis nodosa and of hypersensitivity. Am J Pathol. 1948; 24(4):889-917. PMC: 1942737. View

14.

Cream J, Gumpel J, PEACHEY R . Schönlein-Henoch purpura in the adult. A study of 77 adults with anaphylactoid or Schönlein-Henoch purpura. Q J Med. 1970; 39(156):461-84. View

15.

Wakefield A, Sankey E, Dhillon A, Sawyerr A, More L, Sim R . Granulomatous vasculitis in Crohn's disease. Gastroenterology. 1991; 100(5 Pt 1):1279-87. View

16.

YENTIS I . Henoch-Schönlein purpura mimicking acute appendicitis and Crohn's disease. Br J Radiol. 1973; 46(547):555-6. DOI: 10.1259/0007-1285-46-547-555. View

17.

Shum D, Guenther L . Metastatic Crohn's disease. Case report and review of the literature. Arch Dermatol. 1990; 126(5):645-8. DOI: 10.1001/archderm.126.5.645. View

18.

Yamamura M, Uyemura K, Deans R, Weinberg K, Rea T, Bloom B . Defining protective responses to pathogens: cytokine profiles in leprosy lesions. Science. 1991; 254(5029):277-9. DOI: 10.1126/science.254.5029.277. View