Inflammatory Bowel Disease and Ankylosing Spondylitis Associated with Cutaneous Vasculitis, Glomerulonephritis, and Circulating IgA Immune Complexes

Overview

Journal Ann Rheum Dis

Specialty Rheumatology

Date 1990 Aug 1

PMID 2204314

Citations 21

Authors

A J Peeters

A W van den Wall Bake

M R Daha

F C Breeveld

Affiliations

Soon will be listed here.

Abstract

Two patients both with inflammatory bowel disease (IBD) and ankylosing spondylitis (AS) developed leucocytoclastic vasculitis of the skin and nephropathy. Immunofluorescence studies showed that there was perivascular deposition of immunoglobulin A in the skin biopsy specimens of both patients and in the renal mesangium of one patient. Serum samples of the two patients contained IgA immune complexes. The absence of previous reports on such a combination of symptoms in IBD or AS suggests that these patients may have a disease entity which is distinct from uncomplicated IBD or AS, and which may combine the immunopathological features of both underlying disorders.

Citing Articles

Cutaneous leukocytoklastic vasculitis in a patient with ankylosing spondylitis: A case report.

Xing Y, Zhuang C, Yu Q, Liu C, Xu M, Zhao L Heliyon. 2024; 10(6):e28134.

PMID: 38524579 PMC: 10958421. DOI: 10.1016/j.heliyon.2024.e28134.

Renal and Urological Disorders Associated With Inflammatory Bowel Disease.

Kumar S, Pollok R, Goldsmith D Inflamm Bowel Dis. 2022; 29(8):1306-1316.

PMID: 35942657 PMC: 10393213. DOI: 10.1093/ibd/izac140.

[Update on immunoglobulin A vasculitis].

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PMID: 35303751 PMC: 8932091. DOI: 10.1007/s00393-022-01162-z.

Inflammatory bowel disease in patients undergoing renal biopsies.

Pohjonen J, Nurmi R, Metso M, Oksanen P, Huhtala H, Porsti I Clin Kidney J. 2019; 12(5):645-651.

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Henoch-Schonlein purpura associated with HLA-B27 positive axial spondyloarthritis in a young man.

John K, Sadiq M, Thomas M, Turaka V BMJ Case Rep. 2019; 12(5).

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