Passive Immunization of Mice Against D Factor Blocks Lethality and Cytokine Release During Endotoxemia

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1993 Sep 1

PMID 8350047

Citations 14

Authors

M I Block

M Berg

M J McNamara

J A Norton

D L Fraker

H R Alexander

Affiliations

Soon will be listed here.

Abstract

D factor, also known as leukemia inhibitory factor, is a pleiotropic cytokine whose role during acute injury and inflammation is not known. Intraperitoneal administration of Escherichia coli endotoxin induced D factor gene expression in mice, and passive immunization against D factor protected them from the lethal effects of endotoxin and blocked endotoxin-induced increases in serum levels of interleukin 1 and 6. Peak levels of tumor necrosis factor and interferon gamma were not affected. These results indicate that D factor is an essential early mediator of the inflammatory cytokine response and therefore may be important in the pathogenesis of the many inflammatory conditions, such as sepsis, arthritis, allograft rejection, and cancer immunotherapy.

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