Article: Effect of seasonal allergic rhinitis on airway mucosal absorption of chromium-51 labelled EDTA

Background: Hyperpermeability of the airway mucosa is thought to be characteristic of allergic rhinitis and asthma. Nine subjects with seasonal rhinitis caused by birch pollen were studied and the nasal mucosal absorption of chromium-51 labelled EDTA was examined both in an asymptomatic period before the season and late into the season when significant allergic rhinitis symptoms were present.

Methods: A nasal pool device was used to keep a concentration of the absorption tracer in contact with a larger part of the mucosa of the ipsilateral nasal cavity. Absorption was allowed for 15 minutes and measured as the radioactivity appearing in the 24 hour urine sample.

Results: The nasal absorption of 51Cr-EDTA in subjects with seasonal allergic rhinitis was less during active disease than before the season.

Conclusions: An airway epithelial barrier that is subject to prolonged eosinophilic inflammation may not be disrupted but may rather increase its functional tightness.

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References

1.

Buckle F, Cohen A . Nasal mucosal hyperpermeability to macromolecules in atopic rhinitis and extrinsic asthma. J Allergy Clin Immunol. 1975; 55(4):213-21. DOI: 10.1016/0091-6749(75)90139-6. View

2.

Elwood R, Kennedy S, Belzberg A, Hogg J, Pare P . Respiratory mucosal permeability in asthma. Am Rev Respir Dis. 1983; 128(3):523-7. DOI: 10.1164/arrd.1983.128.3.523. View

3.

Kovacs J, Gill V, Swan J, Ognibene F, Shelhamer J, Parrillo J . Prospective evaluation of a monoclonal antibody in diagnosis of Pneumocystis carinii pneumonia. Lancet. 1986; 2(8497):1-3. DOI: 10.1016/s0140-6736(86)92555-9. View

4.

Ilowite J, Bennett W, Sheetz M, Groth M, Nierman D . Permeability of the bronchial mucosa to 99mTc-DTPA in asthma. Am Rev Respir Dis. 1989; 139(5):1139-43. DOI: 10.1164/ajrccm/139.5.1139. View

5.

Greiff L, PIPKORN U, Alkner U, Persson C . The 'nasal pool' device applies controlled concentrations of solutes on human nasal airway mucosa and samples its surface exudations/secretions. Clin Exp Allergy. 1990; 20(3):253-9. DOI: 10.1111/j.1365-2222.1990.tb02680.x. View

6.

Persson C, Svensson C, Greiff L, Anderson M, Wollmer P, Alkner U . The use of the nose to study the inflammatory response of the respiratory tract. Thorax. 1992; 47(12):993-1000. PMC: 1021088. DOI: 10.1136/thx.47.12.993. View

7.

Persson C, Erjefalt I, Alkner U, Baumgarten C, Greiff L, Gustafsson B . Plasma exudation as a first line respiratory mucosal defence. Clin Exp Allergy. 1991; 21(1):17-24. DOI: 10.1111/j.1365-2222.1991.tb00799.x. View

8.

Greiff L, Wollmer P, PIPKORN U, Persson C . Absorption of 51Cr EDTA across the human nasal airway barriers in the presence of topical histamine. Thorax. 1991; 46(9):630-2. PMC: 463346. DOI: 10.1136/thx.46.9.630. View

9.

Greiff L, Wollmer P, PIPKORN U, Persson C . 125I-albumin may not be used as a tracer of absorption across the human nasal airway barriers. Acta Otolaryngol. 1991; 111(6):1117-21. DOI: 10.3109/00016489109100765. View

10.

Klementsson H, Svensson C, Andersson M, Venge P, PIPKORN U, Persson C . Eosinophils, secretory responsiveness and glucocorticoid-induced effects on the nasal mucosa during a weak pollen season. Clin Exp Allergy. 1991; 21(6):705-10. DOI: 10.1111/j.1365-2222.1991.tb03199.x. View

11.

Gustafsson B, Persson C . Asymmetrical effects of increases in hydrostatic pressure on macromolecular movement across the airway mucosa. A study in guinea-pig tracheal tube preparations. Clin Exp Allergy. 1991; 21(1):121-6. DOI: 10.1111/j.1365-2222.1991.tb00813.x. View

Effect of Seasonal Allergic Rhinitis on Airway Mucosal Absorption of Chromium-51 Labelled EDTA