Mechanisms of Nasal Hyper-reactivity

Overview

Journal Eur Arch Otorhinolaryngol

Specialty Otorhinolaryngology

Date 1995 Jan 1

PMID 7734972

Citations 2

Authors

M Andersson

L Greiff

C Svensson

C Persson

Affiliations

Soon will be listed here.

Abstract

Hyper-reactivity to non-specific challenges has been considered a hallmark of asthma and is defined as an abnormal responsiveness of the bronchial airways to a variety of provocative agents. The mechanisms underlying hyper-reactivity in the upper and lower airways are not known. By using the nose to study the inflammatory response possible abnormalities can be investigated carefully and pathophysiology of specific airway hyper-reactivities can be better understood. Other factors than merely constriction of the bronchial smooth muscles can cause narrowing of the free lumen to airflow. Functionally different and very distinct mucosal end-organ reactivities may also be increased. If these reactivities can be well assessed, specific airway hyper-reactivity can be defined. In the present report, specific mucosal end-organ hyper-reactivities in the allergic nasal mucosa are presented. Certain widespread hypotheses, such as the role of the eosinophil and the "increased absorption permeability theory", are disputed.

Citing Articles

Nasal histamine responses in nonallergic rhinitis with eosinophilic syndrome.

Zambetti G, Ciofalo A, Romeo R, Soldo P, Fusconi M, Greco A Allergy Rhinol (Providence). 2015; 6(2):94-100.

PMID: 26302729 PMC: 4541641. DOI: 10.2500/ar.2015.6.0125.

Airway permeability.

Persson C, Andersson M, Greiff L, Svensson C, Erjefalt J, Sundler F Clin Exp Allergy. 1995; 25(9):807-14.

PMID: 8564718 PMC: 7162050. DOI: 10.1111/j.1365-2222.1995.tb00022.x.

References

Metzger W, Zavala D, Richerson H, Moseley P, Iwamota P, Monick M . Local allergen challenge and bronchoalveolar lavage of allergic asthmatic lungs. Description of the model and local airway inflammation. Am Rev Respir Dis. 1987; 135(2):433-40. DOI: 10.1164/arrd.1987.135.2.433. View

Bacon J, McLean J, Mathews K, Banas J . Priming of the nasal mucosa by ragweed extract or by an irritant (ammonia). J Allergy Clin Immunol. 1981; 67(2):111-6. DOI: 10.1016/0091-6749(81)90005-1. View

Andersson M, von Kogerer B, Andersson P, PIPKORN U . Allergen-induced nasal hyperreactivity appears unrelated to the size of the nasal and dermal immediate allergic reaction. Allergy. 1987; 42(8):631-7. DOI: 10.1111/j.1398-9995.1987.tb00395.x. View

Hargreave F, Ryan G, Thomson N, OByrne P, Latimer K, Juniper E . Bronchial responsiveness to histamine or methacholine in asthma: measurement and clinical significance. J Allergy Clin Immunol. 1981; 68(5):347-55. DOI: 10.1016/0091-6749(81)90132-9. View

Cuss F, DIXON C, Barnes P . Effects of inhaled platelet activating factor on pulmonary function and bronchial responsiveness in man. Lancet. 1986; 2(8500):189-92. DOI: 10.1016/s0140-6736(86)92489-x. View

Boushey H, Holtzman M, Sheller J, Nadel J . Bronchial hyperreactivity. Am Rev Respir Dis. 1980; 121(2):389-413. DOI: 10.1164/arrd.1980.121.2.389. View

Klementsson H, Andersson M . Eosinophil chemotactic activity of topical PAF on the human nasal mucosa. Eur J Clin Pharmacol. 1992; 42(3):295-9. DOI: 10.1007/BF00266351. View

Andersson M, Andersson P, PIPKORN U . Topical glucocorticosteroids and allergen-induced increase in nasal reactivity: relationship between treatment time and inhibitory effect. J Allergy Clin Immunol. 1988; 82(6):1019-26. DOI: 10.1016/0091-6749(88)90139-x. View

Gronborg H, Borum P, Mygind N . Histamine and methacholine do not increase nasal reactivity. Clin Allergy. 1986; 16(6):597-602. DOI: 10.1111/j.1365-2222.1986.tb01999.x. View

10.

Klementsson H, Svensson C, Andersson M, Venge P, PIPKORN U, Persson C . Eosinophils, secretory responsiveness and glucocorticoid-induced effects on the nasal mucosa during a weak pollen season. Clin Exp Allergy. 1991; 21(6):705-10. DOI: 10.1111/j.1365-2222.1991.tb03199.x. View

11.

Andersson M, PIPKORN U . Allergen-induced hyperreactivity is not a feature of dermal immediate allergic reactions--in contrast to reactions of airways mucosa. Clin Allergy. 1988; 18(2):189-96. DOI: 10.1111/j.1365-2222.1988.tb02858.x. View

12.

Salomonsson P, Gronneberg R, Gilljam H, Andersson O, BILLING B, ENANDER I . Bronchial exudation of bulk plasma at allergen challenge in allergic asthma. Am Rev Respir Dis. 1992; 146(6):1535-42. DOI: 10.1164/ajrccm/146.6.1535. View

13.

Flavahan N, Slifman N, Gleich G, Vanhoutte P . Human eosinophil major basic protein causes hyperreactivity of respiratory smooth muscle. Role of the epithelium. Am Rev Respir Dis. 1988; 138(3):685-8. DOI: 10.1164/ajrccm/138.3.685. View

14.

Klementsson H, Andersson M, BAUMGARTEN C, Venge P, PIPKORN U . Changes in non-specific nasal reactivity and eosinophil influx and activation after allergen challenge. Clin Exp Allergy. 1990; 20(5):539-47. DOI: 10.1111/j.1365-2222.1990.tb03147.x. View

15.

Andersson M, PIPKORN U . Immediate and late phase allergic cutaneous reactions are not inducers of unspecific or specific local hyperreactivity. Allergy. 1988; 43(8):597-602. DOI: 10.1111/j.1398-9995.1988.tb00933.x. View

16.

Greiff L, Wollmer P, Svensson C, Andersson M, Persson C . Effect of seasonal allergic rhinitis on airway mucosal absorption of chromium-51 labelled EDTA. Thorax. 1993; 48(6):648-50. PMC: 464598. DOI: 10.1136/thx.48.6.648. View

17.

de Monchy J, Kauffman H, Venge P, Koeter G, Jansen H, SLUITER H . Bronchoalveolar eosinophilia during allergen-induced late asthmatic reactions. Am Rev Respir Dis. 1985; 131(3):373-6. DOI: 10.1164/arrd.1985.131.3.373. View

18.

. Position paper: Immunotherapy. Allergy. 1993; 48(14 Suppl):9-35. DOI: 10.1111/j.1398-9995.1993.tb04754.x. View

19.

Frigas E, Loegering D, Gleich G . Cytotoxic effects of the guinea pig eosinophil major basic protein on tracheal epithelium. Lab Invest. 1980; 42(1):35-43. View

20.

Connell J . Quantitative intranasal pollen challenges. 3. The priming effect in allergic rhinitis. J Allergy. 1969; 43(1):33-44. DOI: 10.1016/0021-8707(69)90018-5. View