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Increased Expression of Interleukin 6 MRNA in Cardiac Myxomas

Overview
Journal Br Heart J
Specialty Cardiology & Vascular Diseases
Date 1993 Jun 1
PMID 8343326
Citations 14
Authors
Y Seino
U Ikeda
K Shimada
Affiliations
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Abstract

In three patients with cardiac myxoma increased expression of interleukin 6 (IL-6) mRNA was found in the myxoma tissue by polymerase chain reaction (PCR) and in situ hybridisation. These cases suggest that IL-6 is overproduced in the myxoma tissue and secreted into the systemic circulatory system. This might contribute to the systemic inflammatory or autoimmune manifestations seen in cardiac myxoma. This study also showed the usefulness of PCR and in situ hybridisation for the evaluation of mRNA expression in small samples of tissue.

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