Phosphatidylserine in the Outer Leaflet of Red Blood Cells from Beta-thalassemia Patients May Explain the Chronic Hypercoagulable State and Thrombotic Episodes

Overview

Journal Am J Hematol

Specialty Hematology

Date 1993 Sep 1

PMID 8342566

Citations 27

Authors

Y Barenholz

E A Rachmilewitz

A Eldor

Affiliations

Soon will be listed here.

Abstract

Investigation of red blood cells from beta-thalassemia patients by means of prothrombinase assay reveals phosphatidylserine in the outer leaflet of the plasma membrane. This might explain their elevated susceptibility to phagocytosis by macrophages and the chronic hypercoagulable state, frequent thrombotic events, and life-long platelet activation that are found in thalassemic patients.

Citing Articles

Beta Thalassemia in Children: Established Approaches, Old Issues, New Non-Curative Therapies, and Perspectives on Healing.

Origa R, Issa L J Clin Med. 2024; 13(22).

PMID: 39598110 PMC: 11594693. DOI: 10.3390/jcm13226966.

Splenectomy is significantly associated with thrombosis but not with pulmonary hypertension in patients with transfusion-dependent thalassemia: a meta-analysis of observational studies.

Kalamara T, Dodos K, Vlachaki E Front Med (Lausanne). 2023; 10:1259785.

PMID: 37886361 PMC: 10598854. DOI: 10.3389/fmed.2023.1259785.

Profile of precipitating factors and its implication in 160 Indian patients with Moyamoya angiopathy.

Das S, Ray B, Pandit A, Ghosh R, Diehl R, Dubey S J Neurol. 2022; 270(3):1654-1661.

PMID: 36477636 PMC: 9734856. DOI: 10.1007/s00415-022-11499-9.

Phosphatidylserine-exposed red blood cells and ineffective erythropoiesis biomarkers in patients with thalassemia.

Chansai S, Yamsri S, Fucharoen S, Fucharoen G, Teawtrakul N Am J Transl Res. 2022; 14(7):4743-4756.

PMID: 35958503 PMC: 9360869.

Thalassemia and Moyamoya syndrome: unfurling an intriguing association.

Das S, Dubey S, Acharya M, Chatterjee S, Lahiri D, Das G J Neurol. 2019; 266(11):2838-2847.

PMID: 31422456 DOI: 10.1007/s00415-019-09497-5.