Age-related Nonrandom Chromosomal Abnormalities in Human Low-grade Astrocytomas

Overview

Journal Hum Genet

Specialty Genetics

Date 1993 Jul 1

PMID 8340108

Citations 5

Authors

G Thiel

T Lozanova

S Vogel

D Kintzel

W JANISCH

R WITKOWSKI

Affiliations

Soon will be listed here.

Abstract

We report a cytogenetic investigation of 55 low-grade astrocytomas in 52 patients, 15 children and 37 adults. In addition to numerical aberrations such as trisomy 7 and gonosomal losses, we found structural and/or numerical aberrations of chromosome 1 in eight astrocytomas. There was a striking difference between the rearranged chromosomes in pediatric and adult patients. Whereas the pediatric tumors revealed monosomies 1p with accompanying trisomy 1q, the astrocytomas in adults showed partial or complete monosomies 1q.

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