Chromosome 1 in Human Colorectal Tumors. Cytogenetic Research on Structural Changes and Their Significance

Overview

Journal Hum Genet

Specialty Genetics

Date 1992 Feb 1

PMID 1740320

Citations 6

Authors

M H COUTURIER-TURPIN

C Esnous

A Louvel

Y Poirier

D Couturier

Affiliations

Soon will be listed here.

Abstract

The significance of short and long arm anomalies of chromosome 1 was investigated in 55 colorectal tumors comprising 41 carcinomas and 14 adenomas. The tumors were at various stages of transformation from adenoma to carcinoma. Our investigation was prompted by the observation of a p32-pter deletion on the short arm of chromosome 1 in a case of benign tubulovillous adenoma with mild dysplasia, as well as by frequent reports that chromosome 1 is involved in many neoplastic processes. Long arm anomalies were found in seven of the 41 carcinomas, six of which were in stage B2, and short arm anomalies in ten carcinomas at various stages. Three of the adenomas exhibited chromosome 1 anomalies, which in one case comprised a 1p32-pter deletion only. Overall, short arm anomalies especially concerned the p32-36 region. These results suggest that the cytogenetic anomalies respectively located on the short and long arms of chromosome 1 should be considered separately. Damage to the long arm might constitute a late non-specific event, whereas damage to the p32-pter region of the short arm might be involved in triggering colorectal tumor development.

Citing Articles

Molecular and cellular pathways associated with chromosome 1p deletions during colon carcinogenesis.

Payne C, Crowley-Skillicorn C, Bernstein C, Holubec H, Bernstein H Clin Exp Gastroenterol. 2011; 4:75-119.

PMID: 21753893 PMC: 3132853. DOI: 10.2147/CEG.S17114.

Isolation and characterization of two novel colon cancer cell lines from Chinese patients.

Hu D, Hwang S, Lin X, Yang P, Tsai C, Huang Q In Vitro Cell Dev Biol Anim. 2007; 43(3-4):105-8.

PMID: 17554590 DOI: 10.1007/s11626-007-9017-5.

Evaluation of 1p losses in primary carcinomas, local recurrences and peripheral metastases from colorectal cancer patients.

Thorstensen L, Qvist H, Heim S, Liefers G, Nesland J, Giercksky K Neoplasia. 2001; 2(6):514-22.

PMID: 11228544 PMC: 1508083. DOI: 10.1038/sj.neo.7900111.

The TP53 tumour suppressor gene in colorectal carcinomas. II. Relation to DNA ploidy pattern and clinicopathological variables.

Meling G, Lothe R, Borresen A, Graue C, Hauge S, Clausen O Br J Cancer. 1993; 67(1):93-8.

PMID: 8427784 PMC: 1968222. DOI: 10.1038/bjc.1993.15.

Thiel G, Lozanova T, Vogel S, Kintzel D, JANISCH W, WITKOWSKI R Hum Genet. 1993; 91(6):547-50.

PMID: 8340108 DOI: 10.1007/BF00205078.

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