Circulating Levels of Colony-stimulating Factor 1 As a Prognostic Indicator in 82 Patients with Epithelial Ovarian Cancer

Overview

Journal Br J Cancer

Specialty Oncology

Date 1994 Feb 1

PMID 8297732

Citations 24

Authors

S M Scholl

C H Bascou

V Mosseri

R Olivares

H Magdelenat

T Dorval

T Palangie

P Validire

P Pouillart

E R Stanley

Affiliations

Soon will be listed here.

Abstract

Serum samples from 82 patients with epithelial ovarian cancer, previously assayed for CA125, were assayed for circulating colony-stimulating factor 1 (CSF-1). An elevated CSF-1 concentration (> 450 U ml-1 or > 5.42 ng ml-1) was significantly associated with a worse survival (P = 0.02). The predictive value of raised CSF-1 levels was retained whether the first available sample for all patients (n = 82) or the first sample at the start of chemotherapy (n = 41) was considered. Mean CSF-1 levels (n = 14) dropped significantly during six courses of platinum-based chemotherapy (P = 0.02). Although an elevated CA125 concentration appeared to be a prognostic indicator in the total population (n = 82), it was not related to prognosis in the group of patients from whom samples had been drawn at the start of chemotherapy. In a Cox proportional hazards model, CSF-1, but not CA125, was significantly associated with outcome following adjustment for stage, grade and degree of surgical clearance.

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