Regulation of Inflammation-primed Activation of Macrophages by Two Serum Factors, Vitamin D3-binding Protein and Albumin

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1993 Dec 1

PMID 8225612

Citations 9

Authors

N Yamamoto

R Kumashiro

M Yamamoto

N P WILLETT

D D LINDSAY

Affiliations

Soon will be listed here.

Abstract

A very small amount (0.0005 to 0.001%) of an ammonium sulfate [50% saturated (NH4)2SO4]-precipitable protein fraction of alpha 2-globulin efficiently supported inflammation-primed activation of macrophages. This fraction contains vitamin D3-binding protein essential for macrophage activation. Comparative macrophage activation studies with fetal calf serum, alpha 2-globulin fraction, 50% (NH4)2SO4 precipitate, and purified bovine vitamin D3-binding protein revealed that fetal calf serum and alpha 2-globulin fraction appear to contain an inhibitor for macrophage activation while ammonium sulfate precipitate contains no inhibitor. This inhibitor was found to be serum albumin. When bovine serum albumin (25 micrograms/ml) was added to a medium supplemented with 0.0005 to 0.05% (NH4)2SO4 precipitate or 1 to 10 ng of vitamin D3-binding protein per ml, activation of macrophages was inhibited.

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References

LINK R, Perlman K, Pierce E, Schnoes H, DeLuca H . Purification of human serum vitamin D-binding protein by 25-hydroxyvitamin D3-Sepharose chromatography. Anal Biochem. 1986; 157(2):262-9. DOI: 10.1016/0003-2697(86)90624-x. View

Yamamoto N, Homma S, Haddad J, Kowalski M . Vitamin D3 binding protein required for in vitro activation of macrophages after alkylglycerol treatment of mouse peritoneal cells. Immunology. 1991; 74(3):420-4. PMC: 1384634. View

Yamamoto N, Ngwenya B, SERY T, Pieringer R . Activation of macrophages by ether analogues of lysophospholipids. Cancer Immunol Immunother. 1987; 25(3):185-92. PMC: 11038200. DOI: 10.1007/BF00199146. View

Yamamoto N, St Claire Jr D, Homma S, Ngwenya B . Activation of mouse macrophages by alkylglycerols, inflammation products of cancerous tissues. Cancer Res. 1988; 48(21):6044-9. View

Cooke N, Haddad J . Vitamin D binding protein (Gc-globulin). Endocr Rev. 1989; 10(3):294-307. DOI: 10.1210/edrv-10-3-294. View

Ngwenya B, Yamamoto N . Contribution of lysophosphatidylcholine-treated nonadherent cells to mechanism of macrophage activation. Proc Soc Exp Biol Med. 1990; 193(2):118-24. DOI: 10.3181/00379727-193-43011. View

Estensen R, White J, Holmes B . Specific degranulation of human polymorphonuclear leukocytes. Nature. 1974; 248(446):347-8. DOI: 10.1038/248347a0. View

Bianco C, Griffin Jr F, Silverstein S . Studies of the macrophage complement receptor. Alteration of receptor function upon macrophage activation. J Exp Med. 1975; 141(6):1278-90. PMC: 2189846. DOI: 10.1084/jem.141.6.1278. View

Pick E, Mizel D . Rapid microassays for the measurement of superoxide and hydrogen peroxide production by macrophages in culture using an automatic enzyme immunoassay reader. J Immunol Methods. 1981; 46(2):211-26. DOI: 10.1016/0022-1759(81)90138-1. View

10.

Coppenhaver D, Sollenne N, BOWMAN B . Post-translational heterogeneity of the human vitamin D-binding protein (group-specific component). Arch Biochem Biophys. 1983; 226(1):218-23. DOI: 10.1016/0003-9861(83)90287-4. View

11.

Ngwenya B, Yamamoto N . Activation of peritoneal macrophages by lysophosphatidylcholine. Biochim Biophys Acta. 1985; 839(1):9-15. DOI: 10.1016/0304-4165(85)90175-8. View

12.

Yang F, Brune J, Naylor S, Cupples R, Naberhaus K, BOWMAN B . Human group-specific component (Gc) is a member of the albumin family. Proc Natl Acad Sci U S A. 1985; 82(23):7994-8. PMC: 391428. DOI: 10.1073/pnas.82.23.7994. View

13.

Cooke N . Rat vitamin D binding protein. Determination of the full-length primary structure from cloned cDNA. J Biol Chem. 1986; 261(7):3441-50. View

14.

Homma S, Yamamoto N . Activation process of macrophages after in vitro treatment of mouse lymphocytes with dodecylglycerol. Clin Exp Immunol. 1990; 79(2):307-13. PMC: 1534768. DOI: 10.1111/j.1365-2249.1990.tb05195.x. View

15.

Homma S, Millman I, Yamamoto N . A serum factor for macrophage activation after in vitro dodecylglycerol treatment of mouse lymphocytes. Immunol Cell Biol. 1990; 68 ( Pt 2):137-42. DOI: 10.1038/icb.1990.19. View

16.

Yang F, Bergeron J, Linehan L, Lalley P, Sakaguchi A, BOWMAN B . Mapping and conservation of the group-specific component gene in mouse. Genomics. 1990; 7(4):509-16. DOI: 10.1016/0888-7543(90)90193-x. View

17.

Yamamoto N, Homma S, Millman I . Identification of the serum factor required for in vitro activation of macrophages. Role of vitamin D3-binding protein (group specific component, Gc) in lysophospholipid activation of mouse peritoneal macrophages. J Immunol. 1991; 147(1):273-80. View

18.

Yamamoto N, Homma S . Vitamin D3 binding protein (group-specific component) is a precursor for the macrophage-activating signal factor from lysophosphatidylcholine-treated lymphocytes. Proc Natl Acad Sci U S A. 1991; 88(19):8539-43. PMC: 52544. DOI: 10.1073/pnas.88.19.8539. View

19.

Yamamoto N, Ngwenya B . Activation of mouse peritoneal macrophages by lysophospholipids and ether derivatives of neutral lipids and phospholipids. Cancer Res. 1987; 47(8):2008-13. View