Effect of Pretreatment with Bacillus Calmette-Guerin on the Course of a Listeria Monocytogenes Infection in Normal and Congenitally Athymic (nude) Mice

Overview

Journal Br J Exp Pathol

Specialty Pathology

Date 1976 Jun 1

PMID 821508

Citations 4

Authors

E J Ruitenberg

L M VAN NOORLE JANSEN

W Kruizinga

P A Steerenberg

Affiliations

Soon will be listed here.

Abstract

The effect of pretreatment with BCG on the course of a Listeria monomcytogenes infection was studied in nu/nu mice and in their heterozygous littermates (+/nu). First, evidence was presented that the nu/nu mice used lacked functional T cells, since BCG treatment resulted only in skin reactivity to tuberculin in +/nu mice and not in nu/nu mice. Acquired resistance to Listeria (based on lower spleen counts) was only obtained in BCG pretreated +/nu mice. Evidence was presented that BCG pretreatment in nu/nu mice failed to increase non-specific resistance, both in terms of spleen counts and survival rate. These results seem to imply that functional T cells are required for this type of non-specific resistance to heterologous antigens. In this connection attention has been drawn to the possible implication of BCG treatment in man.

Citing Articles

Listeria monocytogenes infection affects a subset of Ly49-expressing NK cells in the rat.

Shegarfi H, Naper C, Rolstad B, Inngjerdingen M PLoS One. 2010; 5(12):e15579.

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Enhanced immunological memory responses to Listeria monocytogenes in rodents, as measured by delayed-type hypersensitivity (DTH), adoptive transfer of DTH, and protective immunity, following Lactobacillus casei Shirota ingestion.

De Waard R, Claassen E, Bokken G, Buiting B, Garssen J, Vos J Clin Diagn Lab Immunol. 2003; 10(1):59-65.

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Experimental screening of BCG preparations produced for cancer immunotherapy: safety and immunostimulating and antitumor activity of four consecutively produced batches.

De Jong W, Steerenberg P, Kreeftenberg J, Tiesjema R, Kruizinga W, VAN NOORLE JANSEN L Cancer Immunol Immunother. 1984; 17(1):18-27.

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Effects of macrophage activity on the antibody-dependent cytotoxicity against Trichinella spiralis newborn larvae: an in vitro cytotoxicity and ultrastructural study.

ANTEUNIS A, Astesano A, Ruitenberg E Z Parasitenkd. 1985; 71(2):249-57.

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