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Mitogenicity of Corynebacterium Parvum for Mouse Lymphocytes

Overview
Journal Clin Exp Immunol
Publisher Oxford University Press
Specialty Allergy & Immunology
Date 1975 Dec 1
PMID 817854
Citations 5
Authors
H Zola
Affiliations
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Abstract

Corynebacterium parvum, a powerful in vivo immunostimulant, is shown to stimulate lymphocyte proliferation in vitro. C. parvum is mitogenic for B lymphocytes and does not stimulate T cells. The mitogenicity is dependent on the presence of macrophages. C. diphtheriae and another strain of C. parvum, both of which are devoid of adjuvant, RES stimulation, and tumour-inhibiting activities in vivo are nevertheless mitogenic. A lipid-free fraction from C. parvum, which retains in vivo immunostimulatory properties, is not mitogenic. Thus the mitogenic property is not correlated with the in vivo properties of C. parvum.

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References
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