Reduction of Matrix Metalloproteinase 8-neutrophil Collagenase Levels During Long-term Doxycycline Treatment of Reactive Arthritis

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 1994 Feb 1

PMID 8192476

Citations 8

Authors

A Lauhio

Y T Konttinen

H Tschesche

D Nordstrom

T Salo

J Lahdevirta

L M Golub

T Sorsa

Affiliations

Soon will be listed here.

Abstract

The aim of this work was to determine whether human polymorphonuclear neutrophilic interstitial collagenase (matrix metalloproteinase 8 [MMP-8]) levels are reduced during long-term doxycycline treatment in humans with reactive arthritis. Serum MMP-8 levels were reduced (mean +/- standard error of the mean, 678.9 +/- 185.6 versus 491.2 +/- 144.8 ng of MMP-8 per ml), but not statistically significantly. However, the reduction of salivary MMP-8 levels was statistically significant (3,729 +/- 1,905.3 versus 1,866 +/- 780.0 ng of MMP-8 per ml, P < 0.05). This study demonstrated that a 2-month regimen of doxycycline can reduce MMP-8 levels in serum and especially in body fluids (i.e., saliva) containing inflammatory exudates and thus may contribute to reduced tissue destruction.

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