Gene Structure of the Helicobacter Pylori Cytotoxin and Evidence of Its Key Role in Gastric Disease

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1994 May 1

PMID 8163943

Citations 208

Authors

J L Telford

P Ghiara

M DellOrco

M Comanducci

D Burroni

M Bugnoli

M F Tecce

S Censini

A Covacci

Z Xiang

Affiliations

Soon will be listed here.

Abstract

The gram negative, microaerophilic bacterium Helicobacter pylori colonizes the human gastric mucosa and establishes a chronic infection that is tightly associated with atrophic gastritis, peptic ulcer, and gastric carcinoma. Cloning of the H. pylori cytotoxin gene shows that the protein is synthesized as a 140-kD precursor that is processed to a 94-kD fully active toxin. Oral administration to mice of the purified 94-kD protein caused ulceration and gastric lesions that bear some similarities to the pathology observed in humans. The cloning of the cytotoxin gene and the development of a mouse model of human gastric disease will provide the basis for the understanding of H. pylori pathogenesis and the development of therapeutics and vaccines.

Citing Articles

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