Suppression of Hen Egg Lysozyme-induced Arthritis by Intravenous Antigen Administration: No Role in This for Antigen-driven Bystander Suppression

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1994 Apr 1

PMID 8149664

Citations 2

Authors

M J Jacobs

A E van den Hoek

L B van de Putte

W B van den Berg

Affiliations

Soon will be listed here.

Abstract

The induction of tolerance, particularly by intervention before established immunity, is widely accepted. We studied the effects of intravenous (i.v.) administration of hen egg lysozyme (HEL), before as well as after immunization, on a HEL-induced arthritis. Arthritis and also cartilage destruction were almost completely suppressed when 100 micrograms HEL was injected before immunization. Antigen-specific proliferative T cell responses and IL-2 production in vitro were inhibited. Antigen-specific immunoglobulin and IgG1 titres were equal in control and tolerized mice, in contrast to lowered IgG2a titres in tolerized animals. Detailed histological studies showed that the immune complex-dependent polymorphonuclear cell phase (< 24 h after arthritis induction) was equal for control and HEL-injected mice. Only in the T cell-dependent phase of the arthritis (> 24 h), did suppression become pronounced in tolerized mice. I.v. administration of 100 micrograms HEL after immunization could only marginally reduce infiltrate and exudate, and no reduction of cartilage destruction was seen. An elegant way to interfere in an established immunity can be offered by creation of bystander suppression. We show that i.v. administration of HEL followed by triggering with HEL, at the moment either of immunization or of arthritis induction, does not reduce a methylated bovine serum albumin (BSA)-arthritis. We conclude that arthritis can be suppressed almost totally when HEL is injected intravenously before immunization. Treatment after immunization is less effective. The i.v. induced suppression is T cell-mediated and and antigen-specific: no bystander suppression circuit can be generated.

Citing Articles

Role of IL-2 and IL-4 in exacerbations of murine antigen-induced arthritis.

Jacobs M, van den Hoek A, van Lent P, van De Loo F, van de Putte L, van den Berg W Immunology. 1994; 83(3):390-6.

PMID: 7835964 PMC: 1415042.

Anergy of antigen-specific T lymphocytes is a potent mechanism of intravenously induced tolerance.

Jacobs M, van den Hoek A, van de Putte L, van den Berg W Immunology. 1994; 82(2):294-300.

PMID: 7523288 PMC: 1414807.

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