Sequential Alterations of Periarticular Structures in Antigen-induced Arthritis in Mice. Histological Observations on Fibrous Capsule, Ligaments, Bone and Muscles, Using Whole Joint Sections

Overview

Journal Br J Exp Pathol

Specialty Pathology

Date 1983 Jun 1

PMID 6882678

Citations 16

Authors

M W Kruijsen

W B van den Berg

L B van de Putte

Affiliations

Soon will be listed here.

Abstract

The influence of antigen-induced joint inflammation on periarticular structures was studied in mice on histological sections of whole knee joints prepared at various intervals after arthritis induction. The inflammatory process in the synovial membrane and fluid was associated with alterations in periarticular tissues from the very beginning of inflammation. Muscles nearby the joint became intensely infiltrated by (polymorphonuclear) leucocytes by apparent spreading of the infiltrate out of the synovial tissue into the surrounding muscles. An early destructive effect was found in the bony structures adjacent to the joint leading to erosive changes. The fibrous capsule showed fibroblast proliferation resulting in thickening of the capsule, whereas proliferative changes in the periosteum ultimately resulted in new bone formation. Changes in the fibrous capsule as well as in the periosteum were most pronounced at the sites of severe inflammation and at the sites of attachment of the capsule to the bone, suggesting a role of both the inflammatory process and biomechanical forces in the expression of tissue proliferation. These data indicate that arthritis may profoundly influence periarticular tissues. Whether this results in inflammatory, in proliferative or in destructive changes seems to depend on the structure and the location of the involved tissue.

Citing Articles

Granulocyte macrophage colony-stimulating factor receptor α expression and its targeting in antigen-induced arthritis and inflammation.

Cook A, Louis C, Robinson M, Saleh R, Sleeman M, Hamilton J Arthritis Res Ther. 2016; 18(1):287.

PMID: 27908288 PMC: 5134062. DOI: 10.1186/s13075-016-1185-9.

Adenoviral transfer of murine oncostatin M elicits periosteal bone apposition in knee joints of mice, despite synovial inflammation and up-regulated expression of interleukin-6 and receptor activator of nuclear factor-kappa B ligand.

de Hooge A, van de Loo F, Bennink M, de Jong D, Arntz O, Lubberts E Am J Pathol. 2002; 160(5):1733-43.

PMID: 12000725 PMC: 1850853. DOI: 10.1016/s0002-9440(10)61120-0.

Suppression of hen egg lysozyme-induced arthritis by intravenous antigen administration: no role in this for antigen-driven bystander suppression.

Jacobs M, van den Hoek A, van de Putte L, van den Berg W Clin Exp Immunol. 1994; 96(1):36-42.

PMID: 8149664 PMC: 1534522. DOI: 10.1111/j.1365-2249.1994.tb06226.x.

Cartilage destruction and osteophytes in instability-induced murine osteoarthritis: role of TGF beta in osteophyte formation?.

van den Berg W, van Osch G, van der Kraan P, van Beuningen H Agents Actions. 1993; 40(3-4):215-9.

PMID: 8023746 DOI: 10.1007/BF01984064.

PPD and hsp65 induced monoarthritis initiates spontaneous recurrent flares in Lewis rats.

Ragno S, Morris C, Coumbe A, Mapp P, Colston M, Blake D Ann Rheum Dis. 1995; 54(1):59-65.

PMID: 7880124 PMC: 1005514. DOI: 10.1136/ard.54.1.59.

References

GLYNN L . The chronicity of inflammation and its significance in rheumatoid arthritis. Ann Rheum Dis. 1968; 27(2):105-21. PMC: 1031077. DOI: 10.1136/ard.27.2.105. View

Cooke T, Hurd E, ZIFF M, Jasin H . The pathogenesis of chronic inflammation in experimental antigen-induced arthritis. II. Preferential localization of antigen-antibody complexes to collagenous tissues. J Exp Med. 1972; 135(2):323-38. PMC: 2180529. DOI: 10.1084/jem.135.2.323. View

Mankin H . The reaction of articular cartilage to injury and osteoarthritis (second of two parts). N Engl J Med. 1974; 291(25):1335-40. DOI: 10.1056/NEJM197412192912507. View

Brackertz D, Mitchell G, Mackay I . Antigen-induced arthritis in mice. I. Induction of arthritis in various strains of mice. Arthritis Rheum. 1977; 20(3):841-50. DOI: 10.1002/art.1780200314. View

CROMARTIE W, CRADDOCK J, Schwab J, ANDERLE S, Yang C . Arthritis in rats after systemic injection of streptococcal cells or cell walls. J Exp Med. 1977; 146(6):1585-602. PMC: 2181919. DOI: 10.1084/jem.146.6.1585. View

Teuscher C, Donaldson D . The deposition and formation of immune complexes in collagenous tissues. Clin Immunol Immunopathol. 1979; 13(1):56-66. DOI: 10.1016/0090-1229(79)90020-5. View

Yoneda T, Mundy G . Monocytes regulate osteoclast-activating factor production by releasing prostaglandins. J Exp Med. 1979; 150(2):338-50. PMC: 2185626. DOI: 10.1084/jem.150.2.338. View

Gall E, GALL E . Histopathogenesis of bovine serum. Albumin-induced arthritis in the rabbit. J Rheumatol. 1980; 7(1):13-23. View

Tew J, Mandel T, Rice P . Immune elimination and immune retention: the relationship between antigen retained in the foot and the elicitation of footpad swelling. Immunology. 1980; 40(3):425-33. PMC: 1458048. View

10.

van den Berg W, Kruijsen M, van de Putte L, van Beusekom H, Zwarts W . Antigen-induced and zymosan-induced arthritis in mice: studies on in vivo cartilage proteoglycan synthesis and chondrocyte death. Br J Exp Pathol. 1981; 62(3):308-16. PMC: 2041692. View

11.

van den Berg W, van Beusekom H, van de Putte L, Zwarts W, van der Sluis M . Antigen handling in antigen-induced arthritis in mice: an autoradiographic and immunofluorescence study using whole joint sections. Am J Pathol. 1982; 108(1):9-16. PMC: 1916019. View

12.

Pearson C, WOOD F . Studies of arthritis and other lesions induced in rats by the injection of mycobacterial adjuvant. VII. Pathologic details of the arthritis and spondylitis. Am J Pathol. 1963; 42:73-95. PMC: 1949690. View

13.

MEACHIM G, Collins D . Cell counts of normal and osteoarthritic articular cartilage in relation to the uptake of sulphate (35SO4) in vitro. Ann Rheum Dis. 1962; 21:45-50. PMC: 1007251. DOI: 10.1136/ard.21.1.45. View