Repetitive DNA in and Around Translocation Breakpoints of the Philadelphia Chromosome

Overview

Journal Gene

Specialty Molecular Biology

Date 1994 Mar 25

PMID 8144039

Citations 3

Authors

G Toth

J Jurka

Affiliations

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Abstract

This paper describes systematic sequence studies of repetitive DNA in and around translocation breakpoints on chromosomes 9 and 22, which are involved in the formation of the Philadelphia chromosome in acute leukemias. In addition to Alu repeats described in previous studies, the breakpoint regions appear to contain many other repetitive elements, including a member of a new repetitive family (MER34) reported in this paper. Identification of these repeats broadens current studies on the possible involvement of repetitive DNA in this intensely studied chromosomal translocation.

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