Comparison of in Vitro Susceptibility of Neisseria Gonorrhoeae to Trimethoprim-sulfamethoxazole on Three Different Media

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 1975 Nov 1

PMID 813569

Citations 4

Authors

T T Yoshikawa

S Miyamoto

L B Guze

Affiliations

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Abstract

In vitro susceptibility of 100 clinical isolates of Neisseria gonorrhoeae to trimethoprim-sulfamethoxazole (TMP-SMZ combination; 1:19) was determined by the agar dilution technique using three different media under similar conditions. On Oxoid diagnostic sensitivity test, Mueller-Hinton, and GC agar media, the percentage of isolates inhibited by 2.5 mug or less of TMP per ml and 47.5 mug or less of SMZ per ml were 95, 90, and 84%, respectively. TMP-SMZ appeared to be effective in vitro against N. gonorrhoeae despite differences in the types of media used.

Citing Articles

In vitro activity of Ro 13-9904, cefuroxime, cefoxitin, and ampicillin against Neisseria gonorrhoeae.

Yoshikawa T, Shibata S, Herbert P, Oill P Antimicrob Agents Chemother. 1980; 18(2):355-6.

PMID: 6778381 PMC: 283996. DOI: 10.1128/AAC.18.2.355.

Co-trimoxazole (trimethoprim-sulfamethoxazole): an updated review of its antibacterial activity and clinical efficacy.

Wormser G, Keusch G, Heel R Drugs. 1982; 24(6):459-518.

PMID: 6759092 DOI: 10.2165/00003495-198224060-00002.

Concentrations of trimethoprim-sulfamethoxazole in blood after a single, large oral dose.

Yoshikawa T, Guze L Antimicrob Agents Chemother. 1976; 10(3):462-3.

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In-vitro antimicrobial susceptibility of Neisseria gonorrhoeae in New Zealand.

Green M Br J Vener Dis. 1978; 54(5):316-21.

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