Detoxification of Cyclophosphamide by Human Aldehyde Dehydrogenase Isozymes

Overview

Journal Cancer Lett

Specialty Oncology

Date 1994 Jan 15

PMID 8124665

Citations 14

Authors

U von Eitzen

D P Agarwal

H W GOEDDE

Affiliations

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Abstract

In in vitro studies, no turnover of aldophosphamide and mafosfamide was observed with the tumor-specific aldehyde dehydrogenase 3 isozyme (ALDH3) isolated from human stomach mucosa as well as from lung (A549) and pharynx (UMSCC2) carcinoma cell lines. Only the human liver cytosolic ALDH preparation (ALDH1) showed any significant oxidation of aldophosphamide and mafosfamide.

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