Treating Periodontal Diseases by Blocking Tissue-destructive Enzymes

Overview

Journal J Am Dent Assoc

Publisher Elsevier

Specialty Dentistry

Date 1994 Feb 1

PMID 8113524

Citations 13

Authors

L M Golub

M Wolff

S Roberts

H M Lee

M Leung

G S Payonk

Affiliations

Soon will be listed here.

Abstract

A new therapeutic approach involves the discovery by the "Stony Brook group," that tetracyclines, but not other antibiotics, can inhibit host-derived collagen-destructive enzymes. This newly discovered property of tetracyclines is unrelated to the antimicrobial activity of these drugs. Examples support the hypothesis that this unexpected property of tetracyclines provides a new approach to treating periodontal diseases as well as a variety of medical disorders.

Citing Articles

Pharmacological Therapies for the Management of Inflammatory Bone Resorption in Periodontal Disease: A Review of Preclinical Studies.

Pavanelli A, de Menezes B, Pereira E, de Souza Morais F, Cirelli J, de Molon R Biomed Res Int. 2022; 2022:5832009.

PMID: 35547360 PMC: 9085331. DOI: 10.1155/2022/5832009.

Comparing periodontitis biomarkers in saliva, oral rinse and gingival crevicular fluid: A pilot study.

Katsiki P, Nazmi K, Loos B, Laine M, Schaap K, Hepdenizli E J Clin Periodontol. 2021; 48(9):1250-1259.

PMID: 33998029 PMC: 8453974. DOI: 10.1111/jcpe.13479.

Selective toxicity of antibacterial agents-still a valid concept or do we miss chances and ignore risks?.

Dalhoff A Infection. 2020; 49(1):29-56.

PMID: 33367978 PMC: 7851017. DOI: 10.1007/s15010-020-01536-y.

The effect of laser irradiation and doxycycline application on the production of matrix metalloproteinase-8 and collagen I from cultured human periodontal ligament cells.

Dehdashtizadeh A, Esnaashari N, Farhad S, Ejeian F, Amini S Dent Res J (Isfahan). 2020; 17(3):213-218.

PMID: 32774799 PMC: 7386378.

Chemically-Modified Curcumin 2.24: A Novel Systemic Therapy for Natural Periodontitis in Dogs.

Deng J, Golub L, Lee H, Lin M, Bhatt H, Hong H J Exp Pharmacol. 2020; 12:47-60.

PMID: 32104105 PMC: 7020920. DOI: 10.2147/JEP.S236792.