Combined Effect of Photobiomodulation with a Matrix Metalloproteinase Inhibitor on the Rate of Relapse in Rats

Overview

Journal Angle Orthod

Specialty Dentistry

Date 2015 Jul 9

PMID 26154938

Citations 2

Authors

Sang-Hyun Lee

Kyung-A Kim

Stephanie Anderson

Yoon-Goo Kang

Su-Jung Kim

Affiliations

Soon will be listed here.

Abstract

Objective: To investigate combined effect of photobiomodulation with a matrix metalloproteinase (MMP) inhibitor on the relapse rate in relation to MMP expression in rats.

Materials And Methods: Fifty-two rats were divided into four groups according to the treatment modality: control group, irradiation group, doxycycline group, and irradiation with doxycycline group. During a relapse period of 5 days after orthodontic movement, maxillary central incisors were treated by low-level laser therapy (LLLT) as a photobiomodulation and/or doxycycline as a synthetic MMP inhibitor. Relapse rate was evaluated in association with MMP expression at the gene and protein levels.

Results: Relapse rates were increased by LLLT (1.57-fold) and decreased by doxycycline (0.83-fold) compared with the control, showing positive correlation with the levels of expression for all MMPs in the periodontal ligament (PDL). LLLT concomitant with doxycycline administration resulted in no significant differences of relapse rate and MMP expression from the control.

Conclusions: The combined effect of photobiomodulation with an MMP inhibitor around the relapsing teeth proved to be antagonistic to PDL remodeling activity during relapse. This study suggests a basis for developing a novel biologic procedure targeting the MMP-dependent PDL remodeling to control the relapse rate.

Citing Articles

Comprehensive Effects of Photobiomodulation Therapy as an Adjunct to Post-orthodontic Treatment Care: A Systematic Review.

Shan Z, Wong K, McGrath C, Gu M, Yang Y Oral Health Prev Dent. 2021; 19:203-216.

PMID: 33723980 PMC: 11640779. DOI: 10.3290/j.ohpd.b1075107.

Effect of pharmacological agents on relapse following orthodontic tooth movement.

Veginadu P, Tavva S, Muddada V, Gorantla S Angle Orthod. 2020; 90(4):598-606.

PMID: 33378496 PMC: 8028453. DOI: 10.2319/092619-613.1.

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