Fibroblasts, Myofibroblasts, and Wound Contraction

Overview

Journal J Cell Biol

Specialty Cell Biology

Date 1994 Feb 1

PMID 8106541

Citations 271

Authors

F Grinnell

Affiliations

Soon will be listed here.

Citing Articles

Receptor activity-modifying protein 1 regulates the differentiation of mouse skin fibroblasts by downregulating α-SMA expression via suppression of high mobility group AT-hook 1 to promote skin wound repair.

Song R, Ma J, Yin S, Wu Z, Liu C, Sun R Burns Trauma. 2025; 13():tkae068.

PMID: 39839760 PMC: 11750253. DOI: 10.1093/burnst/tkae068.

Targeting Fibrosis: From Molecular Mechanisms to Advanced Therapies.

Di X, Li Y, Wei J, Li T, Liao B Adv Sci (Weinh). 2024; 12(3):e2410416.

PMID: 39665319 PMC: 11744640. DOI: 10.1002/advs.202410416.

A Core of Keratocan-Negative Cells Survives in Old Corneal Scars.

Joud H, Asgari M, Emerick V, Sun M, Avila M, Margo C Am J Pathol. 2024; 195(2):281-292.

PMID: 39566825 PMC: 11773616. DOI: 10.1016/j.ajpath.2024.10.017.

Hippo pathway in cancer cells induces NCAM1αSMA fibroblasts to modulate tumor microenvironment.

Thinyakul C, Sakamoto Y, Shimoda M, Liu Y, Thongchot S, Reda O Commun Biol. 2024; 7(1):1343.

PMID: 39420139 PMC: 11487161. DOI: 10.1038/s42003-024-07041-4.

Effects of ozone therapy applied topically, by bagging, or both on the healing of clean wounds induced in rat's skin.

Frezza B, Rahal S, Santos I, Silva B, Silva Junior J, Ferreira G Acta Cir Bras. 2024; 39:e397024.

PMID: 39383420 PMC: 11457957. DOI: 10.1590/acb397024.

References

Bellows C, Melcher A, Aubin J . Contraction and organization of collagen gels by cells cultured from periodontal ligament, gingiva and bone suggest functional differences between cell types. J Cell Sci. 1981; 50:299-314. DOI: 10.1242/jcs.50.1.299. View

Finesmith T, Broadley K, Davidson J . Fibroblasts from wounds of different stages of repair vary in their ability to contract a collagen gel in response to growth factors. J Cell Physiol. 1990; 144(1):99-107. DOI: 10.1002/jcp.1041440113. View

Billingham R, Russell P . Studies on wound healing, with special reference to the phenomenon of contracture in experimental wounds in rabbits' skin. Ann Surg. 1956; 144(6):961-81. PMC: 1465358. DOI: 10.1097/00000658-195612000-00005. View

Niewiarowski S, Goldstein S . Interaction of cultured human fibroblasts with fibrin: modification by drugs and aging in vitro. J Lab Clin Med. 1973; 82(4):605-10. View

Watts G, Grillo H, Gross J . Studies in Wound Healing: II. The Role of Granulation Tissue in Contraction. Ann Surg. 1958; 148(2):153-60. PMC: 1450785. DOI: 10.1097/00000658-195808000-00002. View

Kolodney M, Elson E . Correlation of myosin light chain phosphorylation with isometric contraction of fibroblasts. J Biol Chem. 1993; 268(32):23850-5. View

Stopak D, Harris A . Connective tissue morphogenesis by fibroblast traction. I. Tissue culture observations. Dev Biol. 1982; 90(2):383-98. DOI: 10.1016/0012-1606(82)90388-8. View

Jain M, Berg R, Tandon G . Mechanical stress and cellular metabolism in living soft tissue composites. Biomaterials. 1990; 11(7):465-72. DOI: 10.1016/0142-9612(90)90059-y. View

Kasugai S, Suzuki S, Shibata S, Yasui S, Amano H, Ogura H . Measurements of the isometric contractile forces generated by dog periodontal ligament fibroblasts in vitro. Arch Oral Biol. 1990; 35(8):597-601. DOI: 10.1016/0003-9969(90)90025-6. View

10.

Fukamizu H, Grinnell F . Spatial organization of extracellular matrix and fibroblast activity: effects of serum, transforming growth factor beta, and fibronectin. Exp Cell Res. 1990; 190(2):276-82. DOI: 10.1016/0014-4827(90)90197-i. View

11.

Gillery P, Serpier H, Polette M, Bellon G, Clavel C, Wegrowski Y . Gamma-interferon inhibits extracellular matrix synthesis and remodeling in collagen lattice cultures of normal and scleroderma skin fibroblasts. Eur J Cell Biol. 1992; 57(2):244-53. View

12.

Arem A, Madden J . Effects of stress on healing wounds: I. Intermittent noncyclical tension. J Surg Res. 1976; 20(2):93-102. DOI: 10.1016/0022-4804(76)90104-9. View

13.

Guidry C, Grinnell F . Heparin modulates the organization of hydrated collagen gels and inhibits gel contraction by fibroblasts. J Cell Biol. 1987; 104(4):1097-103. PMC: 2114446. DOI: 10.1083/jcb.104.4.1097. View

14.

Lin Y, Grinnell F . Decreased level of PDGF-stimulated receptor autophosphorylation by fibroblasts in mechanically relaxed collagen matrices. J Cell Biol. 1993; 122(3):663-72. PMC: 2119663. DOI: 10.1083/jcb.122.3.663. View

15.

Lambert C, Soudant E, Nusgens B, Lapiere C . Pretranslational regulation of extracellular matrix macromolecules and collagenase expression in fibroblasts by mechanical forces. Lab Invest. 1992; 66(4):444-51. View

16.

Nishiyama T, HORII I, Nakayama Y, Ozawa T, Hayashi T . A distinct characteristic of the quiescent state of human dermal fibroblasts in contracted collagen gel as revealed by no response to epidermal growth factor alone, but a positive growth response to a combination of the growth factor and.... Matrix. 1990; 10(6):412-9. DOI: 10.1016/s0934-8832(11)80149-6. View

17.

Dubertret L, Brunner-Ferber F, Misiti J, Thomas K, Dubertret M . Activities of human acidic fibroblast growth factor in an in vitro dermal equivalent model. J Invest Dermatol. 1991; 97(5):793-8. DOI: 10.1111/1523-1747.ep12486796. View

18.

Harris A, Stopak D, Wild P . Fibroblast traction as a mechanism for collagen morphogenesis. Nature. 1981; 290(5803):249-51. DOI: 10.1038/290249a0. View

19.

Kono T, Tanii T, Furukawa M, Mizuno N, Kitajima J, Ishii M . Cell cycle analysis of human dermal fibroblasts cultured on or in hydrated type I collagen lattices. Arch Dermatol Res. 1990; 282(4):258-62. DOI: 10.1007/BF00371646. View

20.

Nakagawa S, Pawelek P, Grinnell F . Extracellular matrix organization modulates fibroblast growth and growth factor responsiveness. Exp Cell Res. 1989; 182(2):572-82. DOI: 10.1016/0014-4827(89)90260-7. View