Recombinant Collagen for the Repair of Skin Wounds and Photo-aging Damage

Overview

Journal Regen Biomater

Specialty Biomedical Engineering

Date 2024 Sep 26

PMID 39323745

Authors

Taishan Liu

Jiayun Hao

Huan Lei

Yanru Chen

Lin Liu

Liping Jia

Juan Gu

Huaping Kang

Jingjing Shi

Jing He

Yangbin Song

Yuqi Tang

Daidi Fan

Affiliations

Soon will be listed here.

Abstract

The skin, being the body's primary defense mechanism, is susceptible to various injuries such as epidermal wounds, natural aging, and ultraviolet-induced damage. As a result, there is growing interest in researching skin repair methods. Traditional animal-derived collagen, widely available on the market, poses risks due to its immunogenicity and potential for viral contamination. In contrast, recombinant collagen sourced from human genes offers a safer alternative. To investigate the potential of human recombinant collagen in skin repair, our research team applied two types, type I human collagen (Col I) and CF-1552(I), to two different skin injury models: a wound-healing model and a photo-aging model. Our findings indicate that both Col I and CF-1552(I) effectively enhance wound healing and repair skin damaged by ultraviolet exposure. Notably, CF-1552(I) showed effects comparable to Col I in promoting cell proliferation in the wound-healing model and increasing malondialdehyde content in the photo-aging model, suggesting that CF-1552(I) may offer greater potential for skin repair compared to the larger Col I molecule.

Citing Articles

Recombinant Humanized Collagen Enhances Secreted Protein Levels of Fibroblasts and Facilitates Rats' Skin Basement Membrane Reinforcement.

Ye S, Chen B, Jeevithan L, Yang H, Kong Y, Diao X J Funct Biomater. 2025; 16(2).

PMID: 39997581 PMC: 11856143. DOI: 10.3390/jfb16020047.

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