Protective Effects of Vitamins C and E Against Gamma-ray-induced Chromosomal Damage in Mouse

Overview

Journal Int J Radiat Biol

Specialty Radiology

Date 1993 Jun 1

PMID 8100263

Citations 24

Authors

L Sarma

P C Kesavan

Affiliations

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Abstract

The effects of vitamins C and E on bone marrow chromosomes of the mouse exposed to 1 Gy of whole-body gamma-irradiation were studied. These vitamins, dissolved in water/peanut oil, were administered orally as acute doses, either 2 h before, immediately after, or 2 h after irradiation. Both vitamins significantly reduced the frequencies of micronuclei and chromosomal aberrations in bone marrow cells; radioprotection by vitamin E was, however, appreciably greater than that afforded by vitamin C. Administration of the vitamins to mice immediately after irradiation was as effective as that 2 h before irradiation. A sequential treatment consisting of both these vitamins did not result in additional radioprotection over that afforded by vitamin E alone. The probable mechanisms of radioprotection are discussed.

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