Radio-protective Role of Antioxidant Agents

Overview

Journal Oncol Rev

Specialty Oncology

Date 2015 May 21

PMID 25992214

Citations 5

Authors

Alireza Shirazi

Ehsan Mihandoost

Seied Rabie Mahdavi

Mehran Mohseni

Affiliations

Soon will be listed here.

Abstract

Ionizing radiation interacts with biological systems to produce reactive oxygen species and reactive nitrogen species which attack various cellular components. Radio-protectors act as prophylactic agents to shield healthy cells and tissues from the harmful effects of radiation. Past research on synthetic radio-protectors has brought little success, primarily due to the various toxicity-related problems. Results of experimental research show that antioxidant nutrients, such as vitamin E and herbal products and melatonin, are protective against the damaging effects of radiation, with less toxicity and side effects. Therefore, we propose that in the future, antioxidant radio-protective agents may improve the therapeutic index in radiation oncology treatments.

Citing Articles

The Radioprotective Effect of Procaine and Procaine-Derived Product Gerovital H3 in Lymphocytes from Young and Aged Individuals.

Ungurianu A, Margina D, Borsa C, Ionescu C, von Scheven G, Oziol L Oxid Med Cell Longev. 2020; 2020:3580934.

PMID: 32685092 PMC: 7334788. DOI: 10.1155/2020/3580934.

Evaluation of Ameliorative Potential of Vitamins E and C on DNA Double Strand Break (DSB) in Patients Undergoing Computed Tomography (CT): A Clinical Study.

Jafarpour S, Salimian M, Mohseni M, Talari H, Aliasgharzadeh A, Farhood B Int J Mol Cell Med. 2019; 7(4):226-233.

PMID: 31516882 PMC: 6709935. DOI: 10.22088/IJMCM.BUMS.7.4.226.

Rapid disruption of intestinal epithelial tight junction and barrier dysfunction by ionizing radiation in mouse colon in vivo: protection by N-acetyl-l-cysteine.

Shukla P, Gangwar R, Manda B, Meena A, Yadav N, Szabo E Am J Physiol Gastrointest Liver Physiol. 2016; 310(9):G705-15.

PMID: 26822914 PMC: 4867328. DOI: 10.1152/ajpgi.00314.2015.

Consequences of lethal-whole-body gamma radiation and possible ameliorative role of melatonin.

Mihandoost E, Shirazi A, Mahdavi S, Aliasgharzadeh A ScientificWorldJournal. 2014; 2014:621570.

PMID: 25431791 PMC: 4238234. DOI: 10.1155/2014/621570.

Can melatonin help us in radiation oncology treatments?.

Mihandoost E, Shirazi A, Mahdavi S, Aliasgharzadeh A Biomed Res Int. 2014; 2014:578137.

PMID: 24900972 PMC: 4037598. DOI: 10.1155/2014/578137.

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