Hormonal and Immunologic Methods in the Diagnosis and Treatment of Patients with Benign Ovarian Tumors and Endometriotic Cysts

Objective: To compare efficacy of various methods for characterizing endometriosis and benign ovarian tumors.

Design: Two parallel groups of patients, 54 with endometriotic ovarian cysts and 48 with benign tumors.

Setting: Central clinic.

Patients: Patients referred from all regions over a 5-year period.

Outcome Measures: Estrogen Estrogen and progesterone receptor levels of endometrium and endometriotic foci, CA-125 concentration, and estradiol, progesterone, LH, and testosterone blood levels.

Results: LH levels elevated during follicular phase in patients; estradiol levels reduced; receptor levels abnormal in endometriosis, but not in benign ovarian cysts.

Conclusions: Hormone therapy is adequate treatment for endometriotic cysts. CA-125 is not a reliable indicator for differential diagnosis.