Interferon Gamma Regulates Antigen-induced Eosinophil Recruitment into the Mouse Airways by Inhibiting the Infiltration of CD4+ T Cells

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1993 Feb 1

PMID 8093895

Citations 72

Authors

I Iwamoto

H Nakajima

H Endo

S Yoshida

Affiliations

Soon will be listed here.

Abstract

We have previously shown that antigen-induced eosinophil recruitment into the tissue of sensitized mice is mediated by CD4+ T cells and interleukin 5. To determine whether interferon gamma (IFN-gamma) regulates antigen-induced eosinophil recruitment into the tissue, we studied the effect of recombinant (r) murine IFN-gamma and of anti-IFN-gamma monoclonal antibody (mAb) on the eosinophil infiltration of the trachea induced by antigen inhalation in mice. The intraperitoneal administration of rIFN-gamma prevented antigen-induced eosinophil infiltration in the trachea of sensitized mice. The administration of rIFN-gamma also decreased antigen-induced CD4+ T cell but not CD8+ T cell infiltration in the trachea. On the other hand, pretreatment with anti-IFN-gamma mAb enhanced antigen-induced eosinophil and CD4+ T cell infiltration in the trachea. These results indicate that IFN-gamma regulates antigen-induced eosinophil recruitment into the tissue by inhibiting CD4+ T cell infiltration.

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