Calcium-containing Vacuolated Mitochondria During Early Heart Development in Chick Embryos As Demonstrated by Cytochemistry and X-ray Microanalysis

Overview

Journal Anat Embryol (Berl)

Specialties Anatomy & Histology
Reproductive Medicine

Date 1994 May 1

PMID 8092495

Citations 2

Authors

S Komazaki

T Hiruma

Affiliations

Soon will be listed here.

Abstract

The ultrastructure of mitochondria in the developing heart was examined in chick embryos from 2 to 7 days after fertilization. Vacuolated mitochondria were observed in the heart muscle cells of embryos at all stages examined. The number of vacuolated mitochondria as a percentage of total mitochondria in muscle cells was high in embryos at 3 and 4 days and was much higher in the ventricular cells than in the atrial cells. Examination by cytochemistry and X-ray microanalysis revealed the accumulation of calcium in the vacuoles of mitochondria. These results suggest important roles for vacuolated mitochondria in the regulation of the intracellular concentration of calcium during the early development of the chick heart.

Citing Articles

Embryonic lethality and abnormal cardiac myocytes in mice lacking ryanodine receptor type 2.

Takeshima H, Komazaki S, Hirose K, Nishi M, Noda T, Iino M EMBO J. 1998; 17(12):3309-16.

PMID: 9628868 PMC: 1170669. DOI: 10.1093/emboj/17.12.3309.

Calcium-containing, smooth-surfaced endoplasmic reticulum and vacuoles in cells of the blastopore-forming region during gastrulation of the newt, Cynops pyrrhogaster.

Komazaki S Anat Embryol (Berl). 1995; 191(4):369-76.

PMID: 7645763 DOI: 10.1007/BF00534690.

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