The Scientific Challenge of Langerhans Cell Histiocytosis

Overview

Journal Br J Cancer Suppl

Specialty Oncology

Date 1994 Sep 1

PMID 8075011

Authors

P C Beverley

A K Abbas

Affiliations

Soon will be listed here.

Abstract

Langerhans cell histiocytosis is difficult to study because of its rarity. Although recent studies indicate that it may be a clonal proliferation this does not prove that it is a malignant tumour. New methods for culturing dendritic cells and their precursors provide the opportunity to resolve issues relating to clonality, underlying genetic lesions and functional abnormalities in LCH or other lesional cells. The expression of the CD1a antigen on LCH cells provides a target for therapy.

References

Handman E, Ceredig R, Mitchell G . Murine cutaneous leishmaniasis: disease patterns in intact and nude mice of various genotypes and examination of some differences between normal and infected macrophages. Aust J Exp Biol Med Sci. 1979; 57(1):9-29. DOI: 10.1038/icb.1979.2. View

Willman C, Busque L, Griffith B, Favara B, McClain K, Duncan M . Langerhans'-cell histiocytosis (histiocytosis X)--a clonal proliferative disease. N Engl J Med. 1994; 331(3):154-60. DOI: 10.1056/NEJM199407213310303. View

Allan J, Doherty P . Immune T cells can protect or induce fatal neurological disease in murine lymphocytic choriomeningitis. Cell Immunol. 1985; 90(2):401-7. DOI: 10.1016/0008-8749(85)90204-7. View

Goldberg N, Bauer K, Rosen S, CARO W, Marder R, Zugerman C . Histiocytosis X. Flow cytometric DNA-content and immunohistochemical and ultrastructural analysis. Arch Dermatol. 1986; 122(4):446-50. DOI: 10.1001/archderm.122.4.446. View

Baenziger J, Hengartner H, Zinkernagel R, Cole G . Induction or prevention of immunopathological disease by cloned cytotoxic T cell lines specific for lymphocytic choriomeningitis virus. Eur J Immunol. 1986; 16(4):387-93. DOI: 10.1002/eji.1830160413. View

Inaba K, Young J, Steinman R . Direct activation of CD8+ cytotoxic T lymphocytes by dendritic cells. J Exp Med. 1987; 166(1):182-94. PMC: 2188638. DOI: 10.1084/jem.166.1.182. View

Rabkin M, Wittwer C, Kjeldsberg C, Piepkorn M . Flow-cytometric DNA content of histiocytosis X (Langerhans cell histiocytosis). Am J Pathol. 1988; 131(2):283-9. PMC: 1880598. View

Macatonia S, Taylor P, Knight S, Askonas B . Primary stimulation by dendritic cells induces antiviral proliferative and cytotoxic T cell responses in vitro. J Exp Med. 1989; 169(4):1255-64. PMC: 2189250. DOI: 10.1084/jem.169.4.1255. View

McLelland J, Newton J, Malone M, Camplejohn R, Chu A . A flow cytometric study of Langerhans cell histiocytosis. Br J Dermatol. 1989; 120(4):485-91. DOI: 10.1111/j.1365-2133.1989.tb01321.x. View

10.

Zhu X, Dunn J, Phillips R, Goddard A, Paton K, Becker A . Preferential germline mutation of the paternal allele in retinoblastoma. Nature. 1989; 340(6231):312-3. DOI: 10.1038/340312a0. View

11.

Bos J . ras oncogenes in human cancer: a review. Cancer Res. 1989; 49(17):4682-9. View

12.

Porcelli S, Brenner M, Greenstein J, Balk S, Terhorst C, Bleicher P . Recognition of cluster of differentiation 1 antigens by human CD4-CD8-cytolytic T lymphocytes. Nature. 1989; 341(6241):447-50. DOI: 10.1038/341447a0. View

13.

Ornvold K, Carstensen H, Larsen J, Christensen I, Ralfkiaer E . Flow cytometric DNA analysis of lesions from 18 children with langerhans cell histiocytosis (histiocytosis x). Am J Pathol. 1990; 136(6):1301-7. PMC: 1877588. View

14.

Gilliland D, Blanchard K, Levy J, Perrin S, BUNN H . Clonality in myeloproliferative disorders: analysis by means of the polymerase chain reaction. Proc Natl Acad Sci U S A. 1991; 88(15):6848-52. PMC: 52186. DOI: 10.1073/pnas.88.15.6848. View

15.

Nepom G, Erlich H . MHC class-II molecules and autoimmunity. Annu Rev Immunol. 1991; 9:493-525. DOI: 10.1146/annurev.iy.09.040191.002425. View

16.

Inaba K, Steinman R, Pack M, Aya H, Inaba M, Sudo T . Identification of proliferating dendritic cell precursors in mouse blood. J Exp Med. 1992; 175(5):1157-67. PMC: 2119202. DOI: 10.1084/jem.175.5.1157. View

17.

Reid C, Stackpoole A, Meager A, Tikerpae J . Interactions of tumor necrosis factor with granulocyte-macrophage colony-stimulating factor and other cytokines in the regulation of dendritic cell growth in vitro from early bipotent CD34+ progenitors in human bone marrow. J Immunol. 1992; 149(8):2681-8. View

18.

Caux C, Dezutter-Dambuyant C, Schmitt D, Banchereau J . GM-CSF and TNF-alpha cooperate in the generation of dendritic Langerhans cells. Nature. 1992; 360(6401):258-61. DOI: 10.1038/360258a0. View

19.

Hill A, Elvin J, Willis A, Aidoo M, Allsopp C, Gotch F . Molecular analysis of the association of HLA-B53 and resistance to severe malaria. Nature. 1992; 360(6403):434-9. DOI: 10.1038/360434a0. View

20.

Easton D, Bishop D, Ford D, Crockford G . Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium. Am J Hum Genet. 1993; 52(4):678-701. PMC: 1682082. View