Flow-cytometric DNA Content of Histiocytosis X (Langerhans Cell Histiocytosis)

Overview

Journal Am J Pathol

Publisher Elsevier

Specialty Pathology

Date 1988 May 1

PMID 3258734

Citations 6

Authors

M S Rabkin

C T Wittwer

C R Kjeldsberg

M W Piepkorn

Affiliations

Soon will be listed here.

Abstract

Retrospective DNA-content analysis was performed by flow cytometry on formalin-fixed, paraffin-embedded tissue from 36 patients with histiocytosis X (Langerhans cell histiocytosis). Included were 17 patients with solitary bone lesions, 4 patients with multiple bone lesions, 2 patients with solitary extraosseous lesions, 1 patient with congenital self-healing histiocytosis, and 12 patients with disseminated disease. The diagnosis was in each case verified by review of the clinical history and histopathologic material. None of the cases displayed significant cytologic atypia. DNA content analysis failed to reveal additional G0-G1 peaks or "shoulders" suggestive of aneuploid subpopulations in any case. Full-peak coefficients of variation ranged from 3.8 to 8.0. Our data suggest that despite a prior report of a single aneuploid case of histiocytosis X, DNA content analysis may not be useful in predicting clinical stage and outcome in this disease.

Citing Articles

Cytogenetic abnormalities in Langerhans cell histiocytosis.

Betts D, Leibundgut K, Feldges A, Pluss H, Niggli F Br J Cancer. 1998; 77(4):552-5.

PMID: 9484810 PMC: 2149945. DOI: 10.1038/bjc.1998.89.

Langerhans' cell histiocytosis: possible association with malignant germ cell tumour.

Ng W, Lam K, Ng I J Clin Pathol. 1995; 48(10):963-5.

PMID: 8537500 PMC: 502957. DOI: 10.1136/jcp.48.10.963.

The scientific challenge of Langerhans cell histiocytosis.

Beverley P, Abbas A Br J Cancer Suppl. 1994; 23:S61-3.

PMID: 8075011 PMC: 2149700.

Detection of clonal histiocytes in Langerhans cell histiocytosis: biology and clinical significance.

Willman C Br J Cancer Suppl. 1994; 23:S29-33.

PMID: 7521201 PMC: 2149702.

Histiocytosis X: response to chemotherapy.

McLelland J, Broadbent V J R Soc Med. 1989; 82(2):122.

PMID: 2784504 PMC: 1292018.

References

Enriquez P, Dahlin D, HAYLES A, HENDERSON E . Histiocytosis X: a clinical study. Mayo Clin Proc. 1967; 42(2):88-99. View

OBERMAN H . A clinicopathologic study of 40 cases and review of the literature on eosinophilic granuloma of bone. Hand-Schuller-Christian disease and Letterer-Siwe disease. Pediatrics. 1961; 28:307-27. View

Lieberman P, Jones C, DARGEON H, BEGG C . A reappraisal of eosinophilic granuloma of bone, Hand-Schüller-Christian syndrome and Letterer-Siwe syndrome. Medicine (Baltimore). 1969; 48(5):375-400. DOI: 10.1097/00005792-196909000-00002. View

Hashimoto K, Pritzker M . Electron microscopic study of reticulohistiocytoma. An unusual case of congenital, self-healing reticulohistiocytosis. Arch Dermatol. 1973; 107(2):263-70. View

NEZELOF C, Basset F, Rousseau M . Histiocytosis X histogenetic arguments for a Langerhans cell origin. Biomedicine. 1973; 18(5):365-71. View

NEWTON Jr W, Hamoudi A . Histiocytosis: a histologic classification with clinical correlation. Perspect Pediatr Pathol. 1973; 1:251-83. View

LAHEY E . Histiocytosis x--an analysis of prognostic factors. J Pediatr. 1975; 87(2):184-9. DOI: 10.1016/s0022-3476(75)80576-2. View

Frederiksen P, Thommesen P . Histiocytosis X. II. Histologic appearance correlated to prognosis and extent of disease. Acta Radiol Oncol Radiat Phys Biol. 1978; 17(1):10-6. DOI: 10.3109/02841867809127686. View

Daneshbod K, KISSANE J . Idiopathic differentiated histiocytosis. Am J Clin Pathol. 1978; 70(3):381-9. DOI: 10.1093/ajcp/70.3.381. View

10.

NEZELOF C . Disseminated histiocytosis X: analysis of prognostic factors based on a retrospective study of 50 cases. Cancer. 1979; 44(5):1824-38. DOI: 10.1002/1097-0142(197911)44:5<1824::aid-cncr2820440542>3.0.co;2-j. View

11.

Greenberger J, Cassady J, Jaffe N, VAWTER G, Crocker A . Radiation therapy in patients with histiocytosis: management of diabetes insipidus and bone lesions. Int J Radiat Oncol Biol Phys. 1979; 5(10):1749-55. DOI: 10.1016/0360-3016(79)90556-x. View

12.

Williams J, DORFMAN R . Lymphadenopathy as the initial manifestation of histiocytosis X. Am J Surg Pathol. 1979; 3(5):405-21. DOI: 10.1097/00000478-197910000-00003. View

13.

Murphy G, Bhan A, Sato S, Mihm Jr M, Harrist T . A new immunologic marker for human Langerhans cells. N Engl J Med. 1981; 304(13):791-2. DOI: 10.1056/NEJM198103263041320. View

14.

Greenberger J, Crocker A, VAWTER G, Jaffe N, Cassady J . Results of treatment of 127 patients with systemic histiocytosis. Medicine (Baltimore). 1981; 60(5):311-38. DOI: 10.1097/00005792-198109000-00001. View

15.

WOLFSON S, Botero F, Hurwitz S, Pearson H . "Pure" cutaneous histiocytosis-X. Cancer. 1981; 48(10):2236-8. DOI: 10.1002/1097-0142(19811115)48:10<2236::aid-cncr2820481019>3.0.co;2-g. View

16.

Gustafson H, Tribukait B, Esposti P . DNA pattern, histological grade and multiplicity related to recurrence rate in superficial bladder tumours. Scand J Urol Nephrol. 1982; 16(2):135-9. DOI: 10.3109/00365598209179742. View

17.

Morhenn V, Benike C, Charron D, Cox A, Mahrle G, Wood G . Use of the fluorescence-activated cell sorter to quantitate and enrich for subpopulations of human skin cells. J Invest Dermatol. 1982; 79(5):277-82. DOI: 10.1111/1523-1747.ep12500077. View

18.

Risdall R, Dehner L, Duray P, Kobrinsky N, Robison L, Nesbit Jr M . Histiocytosis X (Langerhans' cell histiocytosis). Prognostic role of histopathology. Arch Pathol Lab Med. 1983; 107(2):59-63. View

19.

Barlogie B, Raber M, Schumann J, Johnson T, Drewinko B, Swartzendruber D . Flow cytometry in clinical cancer research. Cancer Res. 1983; 43(9):3982-97. View

20.

Favara B, McCarthy R, Mierau G . Histiocytosis X. Hum Pathol. 1983; 14(8):663-76. DOI: 10.1016/s0046-8177(83)80138-5. View