Article: Antibody-mediated clearance of viruses from the mammalian central nervous system

The novel role of antibody in clearing virus from the central nervous system without the help of other immune effectors is an important phenomenon that has only recently been documented. Possible routes for antibodies across the blood-brain barrier and how they work in the CNS are discussed here.

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References

1.

Doherty P, GERHARD W . Breakdown of the blood--cerebrospinal fluid barrier to immunoglobulin in mice injected intracerebrally with a neurotropic influenza A virus. Post-exposure treatment with monoclonal antibody promotes recovery. J Neuroimmunol. 1981; 1(3):227-37. DOI: 10.1016/0165-5728(81)90027-8. View

2.

Schumacher C, Dietzschold B, Ertl H, Niu H, Rupprecht C, KOPROWSKI H . Use of mouse anti-rabies monoclonal antibodies in postexposure treatment of rabies. J Clin Invest. 1989; 84(3):971-5. PMC: 329743. DOI: 10.1172/JCI114260. View

3.

Schneider-Schaulies S, Liebert U, Segev Y, Rager-Zisman B, Wolfson M, Ter Meulen V . Antibody-dependent transcriptional regulation of measles virus in persistently infected neural cells. J Virol. 1992; 66(9):5534-41. PMC: 289112. DOI: 10.1128/JVI.66.9.5534-5541.1992. View

4.

Zlokovic B, Skundric D, Segal M, Lipovac M, Mackic J, DAVSON H . A saturable mechanism for transport of immunoglobulin G across the blood-brain barrier of the guinea pig. Exp Neurol. 1990; 107(3):263-70. DOI: 10.1016/0014-4886(90)90144-h. View

5.

Levine B, Hardwick J, Trapp B, Crawford T, Bollinger R, Griffin D . Antibody-mediated clearance of alphavirus infection from neurons. Science. 1991; 254(5033):856-60. DOI: 10.1126/science.1658936. View

6.

Wright K, Buchmeier M . Antiviral antibodies attenuate T-cell-mediated immunopathology following acute lymphocytic choriomeningitis virus infection. J Virol. 1991; 65(6):3001-6. PMC: 240949. DOI: 10.1128/JVI.65.6.3001-3006.1991. View

7.

Weihe E, Nohr D, Muller S, Buchler M, Friess H, Zentel H . The tachykinin neuroimmune connection in inflammatory pain. Ann N Y Acad Sci. 1991; 632:283-95. DOI: 10.1111/j.1749-6632.1991.tb33116.x. View

8.

Baldridge J, Buchmeier M . Mechanisms of antibody-mediated protection against lymphocytic choriomeningitis virus infection: mother-to-baby transfer of humoral protection. J Virol. 1992; 66(7):4252-7. PMC: 241229. DOI: 10.1128/JVI.66.7.4252-4257.1992. View

9.

Allan J, Doherty P . Immune T cells can protect or induce fatal neurological disease in murine lymphocytic choriomeningitis. Cell Immunol. 1985; 90(2):401-7. DOI: 10.1016/0008-8749(85)90204-7. View

10.

Koschel K . Coupling of viral membrane proteins to phosphatidylinositide signalling system. FEBS Lett. 1989; 247(2):185-8. DOI: 10.1016/0014-5793(89)81330-4. View

11.

Dermietzel R, Krause D . Molecular anatomy of the blood-brain barrier as defined by immunocytochemistry. Int Rev Cytol. 1991; 127:57-109. DOI: 10.1016/s0074-7696(08)60692-0. View

Antibody-mediated Clearance of Viruses from the Mammalian Central Nervous System