The Absence of IgE Antibody-mediated Augmentation of Immune Responses in CD23-deficient Mice

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1994 Jul 19

PMID 8041705

Citations 29

Authors

H Fujiwara

H Kikutani

S Suematsu

T Naka

K Yoshida

T Tanaka

M Suemura

N Matsumoto

S Kojima

Affiliations

Soon will be listed here.

Abstract

The CD23 antigen, a low-affinity receptor for IgE (Fc epsilon RII), is a type II membrane-bound glycoprotein expressed on various cells, particularly mature B cells. A number of functions have been ascribed to CD23, including specific regulation of IgE production, IgE-mediated cytotoxicity and release of mediators, IgE-dependent antigen focusing, promotion of B-cell growth, prevention of germinal center B cells from apoptosis, proliferation of myeloid precursors, and maturation of early thymocytes. It is not clear whether these activities represent in vivo functions. To explore in vivo functions of CD23, we have produced CD23-deficient mice. These mice displayed normal lymphocyte differentiation and could mount normal antibody responses, including IgE responses upon immunization with T-dependent antigens and infection with Nippostrongyrus brasiliensis. Germinal center formation after immunization and in vitro proliferative response of B cells were not affected in mutant mice. However, antigen-specific IgE-mediated enhancement of antibody responses was severely impaired.

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References

Sarfati M, Delespesse G . Possible role of human lymphocyte receptor for IgE (CD23) or its soluble fragments in the in vitro synthesis of human IgE. J Immunol. 1988; 141(7):2195-9. View

Sutton B, Gould H . The human IgE network. Nature. 1993; 366(6454):421-8. DOI: 10.1038/366421a0. View

Gordon J, Cairns J, Millsum M, Gillis S, Guy G . Interleukin 4 and soluble CD23 as progression factors for human B lymphocytes: analysis of their interactions with agonists of the phosphoinositide "dual pathway" of signalling. Eur J Immunol. 1988; 18(10):1561-5. DOI: 10.1002/eji.1830181014. View

Mansour S, Thomas K, Capecchi M . Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. Nature. 1988; 336(6197):348-52. DOI: 10.1038/336348a0. View

Uchibayashi N, Kikutani H, Barsumian E, Hauptmann R, Schneider F, Schwendenwein R . Recombinant soluble Fc epsilon receptor II (Fc epsilon RII/CD23) has IgE binding activity but no B cell growth promoting activity. J Immunol. 1989; 142(11):3901-8. View

Kehry M, Yamashita L . Low-affinity IgE receptor (CD23) function on mouse B cells: role in IgE-dependent antigen focusing. Proc Natl Acad Sci U S A. 1989; 86(19):7556-60. PMC: 298104. DOI: 10.1073/pnas.86.19.7556. View

Bonnefoy J, Shields J, Mermod J . Inhibition of human interleukin 4-induced IgE synthesis by a subset of anti-CD23/Fc epsilon RII monoclonal antibodies. Eur J Immunol. 1990; 20(1):139-44. DOI: 10.1002/eji.1830200120. View

Mossalayi M, Lecron J, Dalloul A, Sarfati M, Bertho J, Hofstetter H . Soluble CD23 (Fc epsilon RII) and interleukin 1 synergistically induce early human thymocyte maturation. J Exp Med. 1990; 171(3):959-64. PMC: 2187780. DOI: 10.1084/jem.171.3.959. View

Mossalayi M, Arock M, Bertho J, Blanc C, Dalloul A, Hofstetter H . Proliferation of early human myeloid precursors induced by interleukin-1 and recombinant soluble CD23. Blood. 1990; 75(10):1924-7. View

10.

Pirron U, Schlunck T, Prinz J, Rieber E . IgE-dependent antigen focusing by human B lymphocytes is mediated by the low-affinity receptor for IgE. Eur J Immunol. 1990; 20(7):1547-51. DOI: 10.1002/eji.1830200721. View

11.

Letellier M, Nakajima T, Pulido-Cejudo G, Hofstetter H, Delespesse G . Mechanism of formation of human IgE-binding factors (soluble CD23): III. Evidence for a receptor (Fc epsilon RII)-associated proteolytic activity. J Exp Med. 1990; 172(3):693-700. PMC: 2188566. DOI: 10.1084/jem.172.3.693. View

12.

McMahon A, Bradley A . The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain. Cell. 1990; 62(6):1073-85. DOI: 10.1016/0092-8674(90)90385-r. View

13.

Borish L, Mascali J, Rosenwasser L . IgE-dependent cytokine production by human peripheral blood mononuclear phagocytes. J Immunol. 1991; 146(1):63-7. View

14.

Mudde G, Hansel T, von Reijsen F, Osterhoff B, Bruijnzeel-Koomen C . IgE: an immunoglobulin specialized in antigen capture?. Immunol Today. 1990; 11(12):440-3. DOI: 10.1016/0167-5699(90)90172-6. View

15.

Luo H, Hofstetter H, Banchereau J, Delespesse G . Cross-linking of CD23 antigen by its natural ligand (IgE) or by anti-CD23 antibody prevents B lymphocyte proliferation and differentiation. J Immunol. 1991; 146(7):2122-9. View

16.

Liu Y, Cairns J, Holder M, Abbot S, Jansen K, Bonnefoy J . Recombinant 25-kDa CD23 and interleukin 1 alpha promote the survival of germinal center B cells: evidence for bifurcation in the development of centrocytes rescued from apoptosis. Eur J Immunol. 1991; 21(5):1107-14. DOI: 10.1002/eji.1830210504. View

17.

Richards M, Katz D, Liu F . Complete genomic sequence of the murine low affinity Fc receptor for IgE. Demonstration of alternative transcripts and conserved sequence elements. J Immunol. 1991; 147(3):1067-74. View

18.

Laird P, Zijderveld A, Linders K, Rudnicki M, Jaenisch R, Berns A . Simplified mammalian DNA isolation procedure. Nucleic Acids Res. 1991; 19(15):4293. PMC: 328579. DOI: 10.1093/nar/19.15.4293. View

19.

Maeda K, Burton G, Padgett D, Conrad D, Huff T, Masuda A . Murine follicular dendritic cells and low affinity Fc receptors for IgE (Fc epsilon RII). J Immunol. 1992; 148(8):2340-7. View

20.

Aubry J, Pochon S, Graber P, Jansen K, Bonnefoy J . CD21 is a ligand for CD23 and regulates IgE production. Nature. 1992; 358(6386):505-7. DOI: 10.1038/358505a0. View