Stimulation of Cyclic AMP Secretion in Vero Cells by Enterotoxins of Escherichia Coli and Vibrio Cholerae

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1978 Aug 1

PMID 80381

Citations 2

Authors

S Stavric

J I Speirs

J KONOWALCHUK

D Jeffrey

Affiliations

Soon will be listed here.

Abstract

The morphological response of Vero cells to Escherichia coli heat-labile enterotoxin was similar to that of cholera toxin and was accompanied by increases in the intracellular level of cyclic AMP. The effects of both enterotoxins were enhanced by the presence of phosphodiesterase inhibitor and inhibited by heat or specific antisera. Accumulation of cyclic AMP preceded the morphological response.

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