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Polycythaemia Rubra Vera Transforming to Acute Lymphoblastic Leukaemia with a Common Immunophenotype

Overview
Journal J Clin Pathol
Specialty Pathology
Date 1994 May 1
PMID 8027406
Citations 6
Authors
J R Neilson
W N Patton
M D Williams
E E Mayne
B J Boughton
Affiliations
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Abstract

Lymphoblastic transformation of polycythaemia rubra vera is an extremely rare phenomenon. A case of a 76 year old man with polycythaemia rubra vera who developed acute lymphoblastic leukaemia (ALL) 16 years after his initial diagnosis is reported. Membrane markers showed a CD10 positive (common ALL) immunophenotype. To our knowledge this association has not been previously recorded. The rare occurrence of ALL in polycythaemia rubra vera may indicate that in a minority of patients clonal expansion of an abnormal pluripotent haemopoietic stem cell is responsible for the polycythaemia rubra vera disease phenotype.

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