AFC1, a LAMMER Kinase from Arabidopsis Thaliana, Activates STE12-dependent Processes in Yeast

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1994 Dec 6

PMID 7991592

Citations 13

Authors

J Bender

G R Fink

Affiliations

Soon will be listed here.

Abstract

In the yeast Saccharomyces cerevisiae a kinase cascade activates the transcription factor STE12 leading to mating in haploid cells and pseudohyphal growth in diploid cells. To investigate related signal transduction pathways in higher plants, we have isolated a putative protein kinase gene from Arabidopsis thaliana that restores STE12-dependent functions to yeast with mutations in this signal transduction pathway. This Arabidopsis gene, AFC1, induces three STE12-dependent processes even in signal transduction-defective yeast strains: mating-specific gene expression in haploid yeast, mating of haploid yeast to yield diploids, and pseudohyphal growth in diploid yeast. AFC1 has no effect on transcription of the STE12 gene and, instead, is likely to activate the STE12 protein. However, AFC1 has only limited homology to FUS3 and KSS1, the endogenous yeast kinase regulators of STE12. AFC1 is a member of a recently described CDC2-related kinase subfamily, the LAMMER kinases. A close AFC1 homolog, AFC2, lacks STE12 activation phenotypes, indicating the specificity of AFC1. The phenotypes of AFC1 in yeast provide us with tools to elucidate the role of this kinase in Arabidopsis.

Citing Articles

Pleiotropic roles of LAMMER kinase, Lkh1 in stress responses and virulence of .

Kwon S, Choi Y, Kim E, Lee K, Bahn Y, Jung K Front Cell Infect Microbiol. 2024; 14:1369301.

PMID: 38774630 PMC: 11106425. DOI: 10.3389/fcimb.2024.1369301.

The Dual-Specificity LAMMER Kinase Affects Stress-Response and Morphological Plasticity in Fungi.

Lim J, Park H Front Cell Infect Microbiol. 2019; 9:213.

PMID: 31275866 PMC: 6593044. DOI: 10.3389/fcimb.2019.00213.

Two Different Transcripts of a LAMMER Kinase Gene Play Opposite Roles in Disease Resistance.

Duan L, Xiao W, Xia F, Liu H, Xiao J, Li X Plant Physiol. 2016; 172(3):1959-1972.

PMID: 27621422 PMC: 5100786. DOI: 10.1104/pp.16.01245.

The role of the Drosophila LAMMER protein kinase DOA in somatic sex determination.

Rabinow L, Samson M J Genet. 2010; 89(3):271-7.

PMID: 20876993 DOI: 10.1007/s12041-010-0038-6.

Dsk1p kinase phosphorylates SR proteins and regulates their cellular localization in fission yeast.

Tang Z, Tsurumi A, Alaei S, Wilson C, Chiu C, Oya J Biochem J. 2007; 405(1):21-30.

PMID: 17362205 PMC: 1925236. DOI: 10.1042/BJ20061523.

References

Rabinow L, Birchler J . A dosage-sensitive modifier of retrotransposon-induced alleles of the Drosophila white locus. EMBO J. 1989; 8(3):879-89. PMC: 400888. DOI: 10.1002/j.1460-2075.1989.tb03449.x. View

Higgins D, Sharp P . Fast and sensitive multiple sequence alignments on a microcomputer. Comput Appl Biosci. 1989; 5(2):151-3. DOI: 10.1093/bioinformatics/5.2.151. View

Elion E, Grisafi P, Fink G . FUS3 encodes a cdc2+/CDC28-related kinase required for the transition from mitosis into conjugation. Cell. 1990; 60(4):649-64. DOI: 10.1016/0092-8674(90)90668-5. View

Dolan J, Fields S . Overproduction of the yeast STE12 protein leads to constitutive transcriptional induction. Genes Dev. 1990; 4(4):492-502. DOI: 10.1101/gad.4.4.492. View

Chang F, Herskowitz I . Identification of a gene necessary for cell cycle arrest by a negative growth factor of yeast: FAR1 is an inhibitor of a G1 cyclin, CLN2. Cell. 1990; 63(5):999-1011. DOI: 10.1016/0092-8674(90)90503-7. View

Howell B, Afar D, Lew J, Douville E, Icely P, Gray D . STY, a tyrosine-phosphorylating enzyme with sequence homology to serine/threonine kinases. Mol Cell Biol. 1991; 11(1):568-72. PMC: 359671. DOI: 10.1128/mcb.11.1.568-572.1991. View

Ben-David Y, Letwin K, Tannock L, Bernstein A, Pawson T . A mammalian protein kinase with potential for serine/threonine and tyrosine phosphorylation is related to cell cycle regulators. EMBO J. 1991; 10(2):317-25. PMC: 452648. DOI: 10.1002/j.1460-2075.1991.tb07952.x. View

Johnson K, Smith K . Molecular cloning of a novel human cdc2/CDC28-like protein kinase. J Biol Chem. 1991; 266(6):3402-7. View

Elledge S, Mulligan J, Ramer S, Spottswood M, Davis R . Lambda YES: a multifunctional cDNA expression vector for the isolation of genes by complementation of yeast and Escherichia coli mutations. Proc Natl Acad Sci U S A. 1991; 88(5):1731-5. PMC: 51098. DOI: 10.1073/pnas.88.5.1731. View

10.

Song D, Dolan J, Yuan Y, Fields S . Pheromone-dependent phosphorylation of the yeast STE12 protein correlates with transcriptional activation. Genes Dev. 1991; 5(5):741-50. DOI: 10.1101/gad.5.5.741. View

11.

Padmanabha R, Gehrung S, Snyder M . The KNS1 gene of Saccharomyces cerevisiae encodes a nonessential protein kinase homologue that is distantly related to members of the CDC28/cdc2 gene family. Mol Gen Genet. 1991; 229(1):1-9. DOI: 10.1007/BF00264206. View

12.

Ninomiya-Tsuji J, Nomoto S, Yasuda H, Reed S, Matsumoto K . Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation. Proc Natl Acad Sci U S A. 1991; 88(20):9006-10. PMC: 52640. DOI: 10.1073/pnas.88.20.9006. View

13.

Elion E, Brill J, Fink G . FUS3 represses CLN1 and CLN2 and in concert with KSS1 promotes signal transduction. Proc Natl Acad Sci U S A. 1991; 88(21):9392-6. PMC: 52723. DOI: 10.1073/pnas.88.21.9392. View

14.

Gimeno C, Ljungdahl P, Styles C, Fink G . Unipolar cell divisions in the yeast S. cerevisiae lead to filamentous growth: regulation by starvation and RAS. Cell. 1992; 68(6):1077-90. DOI: 10.1016/0092-8674(92)90079-r. View

15.

Gietz D, St Jean A, Woods R, Schiestl R . Improved method for high efficiency transformation of intact yeast cells. Nucleic Acids Res. 1992; 20(6):1425. PMC: 312198. DOI: 10.1093/nar/20.6.1425. View

16.

Liu H, KRIZEK J, BRETSCHER A . Construction of a GAL1-regulated yeast cDNA expression library and its application to the identification of genes whose overexpression causes lethality in yeast. Genetics. 1992; 132(3):665-73. PMC: 1205205. DOI: 10.1093/genetics/132.3.665. View

17.

Minet M, Dufour M, Lacroute F . Complementation of Saccharomyces cerevisiae auxotrophic mutants by Arabidopsis thaliana cDNAs. Plant J. 1992; 2(3):417-22. DOI: 10.1111/j.1365-313x.1992.00417.x. View

18.

Peter M, Gartner A, HORECKA J, Ammerer G, Herskowitz I . FAR1 links the signal transduction pathway to the cell cycle machinery in yeast. Cell. 1993; 73(4):747-60. DOI: 10.1016/0092-8674(93)90254-n. View

19.

Errede B, Levin D . A conserved kinase cascade for MAP kinase activation in yeast. Curr Opin Cell Biol. 1993; 5(2):254-60. DOI: 10.1016/0955-0674(93)90112-4. View

20.

Elion E, Satterberg B, Kranz J . FUS3 phosphorylates multiple components of the mating signal transduction cascade: evidence for STE12 and FAR1. Mol Biol Cell. 1993; 4(5):495-510. PMC: 300953. DOI: 10.1091/mbc.4.5.495. View