Production of A and C Variants of Staphylococcal Beta-lactamase by Methicillin-resistant Strains of Staphylococcus Aureus

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 1994 Jul 1

PMID 7979301

Citations 1

Authors

S R Norris

C W Stratton

D S Kernodle

Affiliations

Soon will be listed here.

Abstract

Most methicillin-resistant Staphylococcus aureus (MRSA) strains produce beta-lactamase. To determine whether this enzyme(s) is identical to one or more of the four beta-lactamases produced by methicillin-susceptible strains, the beta-lactamases of 50 MRSA isolates were typed by using substrate profile analysis. Forty type A, no type B, ten type C, and no type D beta-lactamase-producing strains were identified. The beta-lactamase inhibitor sulbactam reduced the MICs of beta-lactamase-labile antibiotics, including ampicillin, penicillin G, and cefazolin, for type A and type C MRSA strains.

Citing Articles

Disc Test for Detecting Staphylococcus aureus Strains Producing Type A and Type C β-Lactamases.

George C, Lahra M, Nguyen T, Gatus B Microbiol Spectr. 2023; 11(4):e0022023.

PMID: 37409947 PMC: 10434206. DOI: 10.1128/spectrum.00220-23.

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