Crohn's Disease and Cancer: a Population-based Cohort Study

Overview

Journal Gastroenterology

Specialty Gastroenterology

Date 1994 Dec 1

PMID 7958678

Citations 58

Authors

P G Persson

P Karlen

O Bernell

C E Leijonmarck

O Brostrom

A Ahlbom

G Hellers

Affiliations

Soon will be listed here.

Abstract

Background/aims: To study the association between Crohn's disease and cancer, we performed a population-based study of 1251 subjects with Crohn's disease diagnosed in Stockholm from 1955 to 1984 and followed in both the National Cancer Register and the National Cause-of-Death Register until 1989.

Methods: For comparisons, regional cancer incidence rates in Stockholm County were used together with individually computed person-years at risk in the Crohn's disease cohort.

Results: Overall, 69 malignancies occurred among 67 individuals as compared with 59.80 expected malignancies (standardized morbidity ratio [SMR] = 1.15; 95% confidence interval, 0.90-1.46). An excess number of cancers of the upper gastrointestinal tract (SMR, 3.05; 95% confidence interval, 1.67-5.11) was observed, mainly because of an increased number of cancers of the small intestine (SMR, 15.64; 95% confidence interval, 4.26-40.06). An increased occurrence of urinary bladder cancer was also observed (SMR, 2.68; 95% confidence interval, 1.08-5.53).

Conclusions: The occurrence of colorectal cancer was not increased.

Citing Articles

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Risk of Lymphoma in Inflammatory Bowel Disease.

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Extraintestinal Cancers in Inflammatory Bowel Disease: A Literature Review.

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Risk of malignant lymphomas in patients with inflammatory bowel disease: a population-based cohort study.

Yu J, Refsum E, Wieszczy P, Helsingen L, Perrin V, Hogden A BMJ Open Gastroenterol. 2023; 10(1).

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Persistently High Rates of Abdominal Computed Tomography Imaging Among Patients With Inflammatory Bowel Disease Who Present to the Emergency Department.

Kandel R, Merlano M, Tan P, Brar G, Mallick R, Macdonald B J Can Assoc Gastroenterol. 2023; 6(2):64-72.

PMID: 37025509 PMC: 10071298. DOI: 10.1093/jcag/gwac029.