Colorectal Malignancy in a Prospective Irish Inflammatory Bowel Disease Population 15 Years Since Diagnosis: Comparison with the EC-IBD Cohort

Overview

Journal Gastroenterol Res Pract

Publisher Wiley

Specialty Gastroenterology

Date 2017 Nov 18

PMID 29147110

Citations 1

Authors

Mary Shuhaibar

Colm OMorain

Affiliations

Soon will be listed here.

Abstract

Background And Aim: As part of the EC-IBD prospective inception cohort study, we had unique opportunity to follow up our patients since diagnosis in the early 1990s.

Patients And Methods: All patients from the greater Dublin area ( = 192) were followed up from inception between 1991 and 1993 until the 30 September 2009. Patients who developed malignancies were logged electronically with verification of the site and histology.

Results: Of the initial 192 patients, 133 were included in the 15-year follow-up. Of those, 80 (60.2%) had UC and 53 (39.8%) had CD. There were 82 (61.7%) males and 51 (38.3%) females. Six patients had extraintestinal malignancy; however, there was no CRC related to IBD noted in our cohort. Four of the 6 identified cases had UC (64%) with a mean age of 54.25 years at the time of cancer diagnosis, whereas the two CD patients had a mean age of 51.5 years at the time of cancer diagnosis.

Conclusion: CRC was not observed in our cohort. The six extraintestinal malignancies did not show significant relation to IBD. The high total colectomy rate (in the prebiological therapy era) may have contributed to low malignancy rate.

Citing Articles

Improving Quality in the Care of Patients with Inflammatory Bowel Diseases.

Egberg M, Gulati A, Gellad Z, Melmed G, Kappelman M Inflamm Bowel Dis. 2018; 24(8):1660-1669.

PMID: 29718299 PMC: 6231366. DOI: 10.1093/ibd/izy030.

References

Leidenius M, Farkkila M, Karkkainen P, Taskinen E, Kellokumpu I, Hockerstedt K . Colorectal dysplasia and carcinoma in patients with ulcerative colitis and primary sclerosing cholangitis. Scand J Gastroenterol. 1997; 32(7):706-11. DOI: 10.3109/00365529708996522. View

Karlen P, Lofberg R, Brostrom O, Leijonmarck C, Hellers G, Persson P . Increased risk of cancer in ulcerative colitis: a population-based cohort study. Am J Gastroenterol. 1999; 94(4):1047-52. DOI: 10.1111/j.1572-0241.1999.01012.x. View

Cairns S, Scholefield J, Steele R, Dunlop M, Thomas H, Evans G . Guidelines for colorectal cancer screening and surveillance in moderate and high risk groups (update from 2002). Gut. 2010; 59(5):666-89. DOI: 10.1136/gut.2009.179804. View

Greenstein A, Gennuso R, Sachar D, Heimann T, Smith H, Janowitz H . Extraintestinal cancers in inflammatory bowel disease. Cancer. 1985; 56(12):2914-21. DOI: 10.1002/1097-0142(19851215)56:12<2914::aid-cncr2820561232>3.0.co;2-j. View

Rutter M, Saunders B, Wilkinson K, Rumbles S, Schofield G, Kamm M . Thirty-year analysis of a colonoscopic surveillance program for neoplasia in ulcerative colitis. Gastroenterology. 2006; 130(4):1030-8. DOI: 10.1053/j.gastro.2005.12.035. View

Choi P, Zelig M . Similarity of colorectal cancer in Crohn's disease and ulcerative colitis: implications for carcinogenesis and prevention. Gut. 1994; 35(7):950-4. PMC: 1374843. DOI: 10.1136/gut.35.7.950. View

Gillen C, Andrews H, Prior P, Allan R . Crohn's disease and colorectal cancer. Gut. 1994; 35(5):651-5. PMC: 1374750. DOI: 10.1136/gut.35.5.651. View

Levin B . Inflammatory bowel disease and colon cancer. Cancer. 1992; 70(5 Suppl):1313-6. DOI: 10.1002/1097-0142(19920901)70:3+<1313::aid-cncr2820701518>3.0.co;2-b. View

Gillen C, Walmsley R, Prior P, Andrews H, Allan R . Ulcerative colitis and Crohn's disease: a comparison of the colorectal cancer risk in extensive colitis. Gut. 1994; 35(11):1590-2. PMC: 1375617. DOI: 10.1136/gut.35.11.1590. View

10.

Gyde S, Prior P, Macartney J, Thompson H, Waterhouse J, Allan R . Malignancy in Crohn's disease. Gut. 1980; 21(12):1024-9. PMC: 1419401. DOI: 10.1136/gut.21.12.1024. View

11.

Jess T, Winther K, Munkholm P, Langholz E, Binder V . Intestinal and extra-intestinal cancer in Crohn's disease: follow-up of a population-based cohort in Copenhagen County, Denmark. Aliment Pharmacol Ther. 2004; 19(3):287-93. DOI: 10.1111/j.1365-2036.2004.01858.x. View

12.

Jess T, Loftus Jr E, Velayos F, Harmsen W, Zinsmeister A, Smyrk T . Risk of intestinal cancer in inflammatory bowel disease: a population-based study from olmsted county, Minnesota. Gastroenterology. 2006; 130(4):1039-46. DOI: 10.1053/j.gastro.2005.12.037. View

13.

Mellemkjaer L, Olsen J, Frisch M, Johansen C, Gridley G, McLaughlin J . Cancer in patients with ulcerative colitis. Int J Cancer. 1995; 60(3):330-3. DOI: 10.1002/ijc.2910600309. View

14.

Marchesa P, Lashner B, Lavery I, Milsom J, Hull T, Strong S . The risk of cancer and dysplasia among ulcerative colitis patients with primary sclerosing cholangitis. Am J Gastroenterol. 1997; 92(8):1285-8. View

15.

Wolters F, Van Zeijl G, Sijbrandij J, Wessels F, OMorain C, Limonard C . Internet-based data inclusion in a population-based European collaborative follow-up study of inflammatory bowel disease patients: description of methods used and analysis of factors influencing response rates. World J Gastroenterol. 2006; 11(45):7152-8. PMC: 4725090. DOI: 10.3748/wjg.v11.i45.7152. View

16.

Eaden J, Mayberry J . Colorectal cancer complicating ulcerative colitis: a review. Am J Gastroenterol. 2000; 95(10):2710-9. DOI: 10.1111/j.1572-0241.2000.02297.x. View

17.

Katsanos K, Tatsioni A, Pedersen N, Shuhaibar M, Hernandez Ramirez V, Politi P . Cancer in inflammatory bowel disease 15 years after diagnosis in a population-based European Collaborative follow-up study. J Crohns Colitis. 2011; 5(5):430-42. DOI: 10.1016/j.crohns.2011.04.013. View

18.

Breslow N, Day N . Statistical methods in cancer research. Volume II--The design and analysis of cohort studies. IARC Sci Publ. 1987; (82):1-406. View

19.

Gilat T, Fireman Z, Grossman A, Hacohen D, KADISH U, Ron E . Colorectal cancer in patients with ulcerative colitis. A population study in central Israel. Gastroenterology. 1988; 94(4):870-7. DOI: 10.1016/0016-5085(88)90541-0. View

20.

Connell W, Kamm M, Dickson M, Balkwill A, Ritchie J, Lennard-Jones J . Long-term neoplasia risk after azathioprine treatment in inflammatory bowel disease. Lancet. 1994; 343(8908):1249-52. DOI: 10.1016/s0140-6736(94)92150-4. View