Novel Features of the Respiratory Tract T-cell Response to Influenza Virus Infection: Lung T Cells Increase Expression of Gamma Interferon MRNA in Vivo and Maintain High Levels of MRNA Expression for Interleukin-5 (IL-5) and IL-10

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1994 Nov 1

PMID 7933145

Citations 36

Authors

N Baumgarth

L Brown

D Jackson

A Kelso

Affiliations

Soon will be listed here.

Abstract

Analysis of the respiratory tract before and after primary influenza virus infection revealed a virus-induced preferential accumulation of a CD8+ T-cell population that coexpresses mRNA for interleukin-5 (IL-5) and IL-10 with virus dose-dependent high levels of gamma interferon. However, cytokine production in lung tissues was not restricted to the T-cell population, since CD3- cells were found to express mRNA for various cytokines, including IL-4 and particularly IL-6 and granulocyte-macrophage colony-stimulating factor. These data provide in vivo evidence for a local respiratory tract immune response to influenza virus infection dominated by cytokine-producing CD8+ T cells.

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