Transgenic Mice Lacking Class I Major Histocompatibility Complex-restricted T Cells Have Delayed Viral Clearance and Increased Mortality After Influenza Virus Challenge

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1992 Apr 11

PMID 1552285

Citations 174

Authors

B S Bender

T Croghan

L Zhang

P A Small Jr

Affiliations

Soon will be listed here.

Abstract

To investigate the role of CD8+ T lymphocytes in recovery from influenza pneumonia, we used transgenic mice either homozygous (-/-) or heterozygous (+/-) for beta 2-microglobulin (beta 2-M) gene disruption. These mice lack major histocompatibility complex-restricted class I (CD8+) T cells. We found that after challenge with a nonlethal influenza virus, the beta 2-M (-/-) mice had significantly delayed pulmonary viral clearance. Furthermore, after challenge with a more virulent influenza virus, the beta 2-M (-/-) mice had a significantly higher mortality rate than did control mice. Thus, CD8+ T cells are important in recovery from virulent influenza infections, but other host defense mechanisms can clear the respiratory tract of more benign infections.

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