A Pathway for Entry of Reoviruses into the Host Through M Cells of the Respiratory Tract

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1994 Oct 1

PMID 7931083

Citations 20

Authors

M J MORIN

A Warner

B N Fields

Affiliations

Soon will be listed here.

Abstract

Many microorganisms gain access to the systemic circulation after entering the respiratory tract. The precise pathways used to cross the mucosal barriers of the lungs have not been clearly described. We have used the mammalian reoviruses in order to determine the pathway that a systemic virus uses to penetrate the mucosal barrier and enter the systemic circulation after entering the airways of the lungs. Reoviruses enter through pulmonary M cells, which overlie bronchus-associated lymphoid tissue, and subsequently spread to regional lymph nodes. Thus, the pathway through M cells represents a strategy by which viruses and probably other microorganisms can penetrate the mucosal surface of the respiratory tract and thereby enter the systemic circulation.

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