FGF-2: Apical Ectodermal Ridge Growth Signal for Chick Limb Development

Overview

Journal Science

Specialty Science

Date 1994 Apr 1

PMID 7908145

Citations 73

Authors

J F Fallon

A Lopez

M A Ros

M P Savage

B B Olwin

B K Simandl

Affiliations

Soon will be listed here.

Abstract

The apical ectodermal ridge permits growth and elongation of amniote limb buds; removal causes rapid changes in mesodermal gene expression, patterned cell death, and truncation of the limb. Ectopic fibroblast growth factor (FGF)-2 supplied to the chick apical bud mesoderm after ridge removal will sustain normal gene expression and cell viability, and allow relatively normal limb development. A bioassay for FGFs demonstrated that FGF-2 was the only detectable FGF in chick limb bud extracts. By distribution and bioactivity, FGF-2 is the prime candidate for the chick limb bud apical ridge growth signal.

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